Early focality and spread of cortical dysfunction in amyotrophic lateral sclerosis: A regional study across the motor cortices

Dharmadasa, Thanuja; Matamala, Jose M.; Howells, James; Vucic, Steve; Kiernan, Matthew C.


Objective: To characterise the regional cortical patterns underlying clinical symptomatology in amyotrophic lateral sclerosis (ALS). Methods: 138 patients prospectively underwent transcranial magnetic stimulation studies from hand and leg cortical regions of each hemisphere, obtaining motor evoked potentials from all four limbs. Patients were categorised by clinical phenotype and underwent clinical and peripheral evaluation of disease. Results: Cortical dysfunction was evident across the motor cortices, with reduction in short-interval intracortical inhibition (SICI) suggesting the presence of widespread cortical hyperexcitability, most prominently from clinically affected regions (hand p 0.0001; leg p 0.01). In early disease, cortical abnormalities were asymmetric between hemispheres, focally corresponding to clinical site-of-onset (p 0.05). Degrees of cortical dysfunction varied between phenotypes, with the bulbar-onset cohort demonstrating greatest reduction in SICI (p = 0.03). Conclusions: The pattern of cortical dysfunction appears linked to clinical evolution in ALS, with early focal asymmetry preceding widespread changes in later disease. Cortical differences across phenotypes may influence clinical variability. Significance: This is the first study to extensively map cortical abnormalities from multiple motor regions across hemispheres. The early cortical signature mirrors symptom laterality, supporting a discrete region of disease onset. Phenotypes appear to exist within a pathophysiological continuum, but cortical heterogeneity may mediate observed differences in clinical outcome. Crown Copyright (C) 2019 Published by Elsevier B.V. on behalf of International Federation of Clinical Neurophysiology. All rights reserved.

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Título según WOS: ID WOS:000520134900024 Not found in local WOS DB
Volumen: 131
Número: 4
Fecha de publicación: 2020
Página de inicio: 958
Página final: 966


Notas: ISI