Comparison of cross-sectional areas and distal-proximal nerve ratios in amyotrophic lateral sclerosis

Noto, Yu-Ichi; Garg, Nidhi; Li, Tiffany; Timmins, Hannah C.; Park, Susanna B.; Shibuya, Kazumoto; Shahrizaila, Nortina; Huynh, William; Matamala, Jose M.; Dharmadasa, Thanuja; Yiannikas, Con; Vucic, Steve; Kiernan, Matthew C.


Introduction: This study explored potential diagnostic markers of nerve ultrasound in differentiating amyotrophic lateral sclerosis (ALS) from mimic disorders. Methods: Ultrasound of the median, ulnar, and tibial nerves was conducted in 53 patients with ALS, 32 patients with ALS-mimic disorders, and 30 controls. Nerve cross-sectional area (CSA) and distal-proximal ratios were calculated. Results: The median nerve CSA in the upper arm was decreased (7.9 +/- 1.3 mm(2) vs. 9.0 +/- 1.4 mm(2), P 0.05), and the median nerve wrist-upper arm ratio was increased in ALS patients compared with controls (1.3 +/- 0.4 vs. 1.1 +/- 0.2; P 0.01). In differentiating ALS from mimic presentations, assessment of median nerve CSA in the upper arm and comparison of a median and ulnar nerve CSA distal-proximal ratio provide diagnostic potential. Discussion: Assessment of nerve CSA combined with calculation of nerve CSA distal-proximal ratio provides a useful marker to aid in the diagnosis of ALS. Muscle Nerve 58:777-783, 2018

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Título según WOS: ID WOS:000453573000009 Not found in local WOS DB
Título de la Revista: MUSCLE NERVE
Volumen: 58
Número: 6
Editorial: John Wiley & Sons Inc.
Fecha de publicación: 2018
Página de inicio: 777
Página final: 783


Notas: ISI