Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae

Aguirre, MC; Delporte C.; Backhouse, N; ERAZO, S; Letelier, ME; CASSELS, BK; Silva, X.; Alegria, S; Negrete, R

Abstract

Leaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material showed that some extracts have potent anti-inflammatory activities. Further fractionation led to the isolation and identification of betulinic acid, a mixture of ursolic and oleanolic acids, and the 2α-hydroxy derivatives alphitolic, asiatic, and corosolic acids. The latter three were evaluated in vivo in the mouse ear assay for their topical anti-inflammatory activity, inducing inflammation with either arachidonic acid (AA) or 12-O-tetradecanoylphorbol-13 acetate (TPA). Only corosolic acid was active in the AA assay, with similar potency to nimesulide, but all three triterpene acids inhibited TPA-induced inflammation with potencies comparable to that of indomethacin. © 2006 Elsevier Ltd. All rights reserved.

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Título según WOS: Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae
Título según SCOPUS: Topical anti-inflammatory activity of 2a-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae
Título de la Revista: BIOORGANIC & MEDICINAL CHEMISTRY
Volumen: 14
Número: 16
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2006
Página de inicio: 5673
Página final: 5677
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0968089606003014
DOI:

10.1016/j.bmc.2006.04.021

Notas: ISI, SCOPUS