Covid-19 in South America: clinical and epidemiological characteristics among 381 patients during the early phase of the pandemic in Santiago, Chile

Vial, Macarena R.; Peters, Anne; Perez, Inia; Spencer-Sandino, Maria; Barbe, Mario; Porte, Lorena; Weitzel, Thomas; Aylwin, Mabel; Vial, Pablo; Araos, Rafael; Munita, Jose M.; CAS-UDD Covid-19 Working Grp

Abstract

BackgroundUnderstanding the characteristics of the Covid-19 pandemic in different geographical regions, ethnic and socioeconomic settings are of emerging importance. This study presents the demographic and clinical features of SARS-CoV-2 infected patients in a large private healthcare center in Santiago, Chile, during the first month of the pandemic.MethodsWe analyzed the demographics, laboratory and clinical characteristics including severity and outcome of all patients diagnosed with Covid-19 during the first month of the pandemic. SARS-2-CoV infection was confirmed by RT-PCR in nosopharyngeal samples. The primary outcome was a composite of ICU admission or all-cause, in-hospital mortality. Clinical and laboratory parameters of hospitalized patients were analyzed regarding their association with the primary outcome.ResultsFrom March 3 to April 4, 2020, 3679 individuals were tested for SARS-CoV-2 in our hospital. Of those, 381 had Covid-19 and were included into this analysis. Most patients (99.2%) were Chileans, 12% returning from recent travel. The median age was 39years (IQR 31-49) and 52% were female. A total of 88 patients (23.1%) were hospitalized; 18 (3.7%) required ICU and/or died. The overall mortality was 0.7%. Increased body mass index (BMI) and elevated C-reactive protein (CRP) were independently associated with ICU care or death.ConclusionDuring the first weeks of the pandemic in Chile, most Covid-19 patients were young, with low rates of hospitalization, ICU requirement, and fatality. BMI and CRP on admission were predictors for severity. Our data provide important information on the clinical course and outcome of Covid-19 in a Latin American setting.

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Título según WOS: ID WOS:000599849300002 Not found in local WOS DB
Título de la Revista: BMC INFECTIOUS DISEASES
Volumen: 20
Número: 1
Editorial: BMC
Fecha de publicación: 2020
DOI:

10.1186/s12879-020-05665-5

Notas: ISI