Antifungal activity of mouthwashes against Candida albicans and Rhodotorula mucilaginosa: An in vitro study

Handschuh Briones, Rodrigo Alejandro; Silva Arcos, Evelyn Nicole; Urrutia, Milton; Godoy-Martinez, Patricio

Abstract

Background: Candida albicans and Rhodotorula mucilaginosa are yeasts of clinical importance in the oral cavity. In immunocompromised patients they can cause some pathologies that must be controlled with antimicrobials. Aims: To evaluate and compare the antimicrobial efficacy of commercially available mouthrinses against strains of C. albicans and R. mucilaginosa. Methods: The six mouthwashes studied in vitro were formulated (alone or in combination) with chlorhexidine (CHX) 0.12%, CHX 0.1%, CHX 0.05%, cetylpyridinium chloride (CPC) 0.075%, CPC 0.05%, and essential oils. Ten C. albicans and R. mucilaginosa isolates each were studied. The agar diffusion method (Mueller Hinton II), with incubation at 32 degrees C was used to evaluate the antifungal activity. Results: The results of this study indicate that mouthwashes with CHX 0.1%, CHX 0.12%, CHX 0.05% + CPC 0.05%, CHX 0.12% + CPC 0.05% and CPC 0.075% have an antifungal effect against C. albicans and R. mucilaginosa. CHX 0.1% led to the broadest inhibition zone for C albicans and R. mucilaginosa (25.65 I 2.39 mm and 40.05 I 3.31 mm). Essential oils did not show any antifungal activity. Statistical analysis showed no statistical difference between mouth rinses CHX 0.1%, CHX 0.12% and CHX 0.12% + CPC 0.05% (p = 0.0001) against C. albicans and R. mucilaginosa. Conclusions: Mouthwashes with CHX showed higher antifungal activity against C. albicans and R. mucilaginosa than other mouthwashes studied. (C) 2020 Published by Elsevier Espaiia, S.L.U. on behalf of Asociacion Espailola de Micologla.

Más información

Título según WOS: ID WOS:000585001100004 Not found in local WOS DB
Título de la Revista: REVISTA IBEROAMERICANA DE MICOLOGIA
Volumen: 37
Número: 2
Editorial: ASOCIACION ESPANOLA MICOLOGIA-AEM
Fecha de publicación: 2020
Página de inicio: 47
Página final: 52
DOI:

10.1016/j.riam.2019.10.006

Notas: ISI