Endothelins in the cat petrosal ganglion and carotid body: Effects and immunolocalization
In response to hypoxia, chemoreceptor cells of the carotid body (CB) release transmitters, which acting on the petrosal ganglion (PG) neuron terminals, increase the chemoafferent discharge. Additionally, vasoactive molecules produced within the CB may modulate hypoxic chemoreception by controlling blood flow and tissue PO 2. Endothelin-1 (ET-1) increases basal CB chemosensory discharges in situ, probably due to its vasoconstrictor action. However, the actions of ET-1 on PG neurons or its expression in the PG are not known. Using immunohistochemistry, we found that endothelin-like peptides are expressed in the cat PG and CB under normoxic conditions. Exogenous applications of ET-1 increased the chemosensory activity in the vascularly perfused CB but were ineffective on either the CB or PG superfused preparations, both of which are devoid of vascular control. Thus, our data indicate that the excitatory effect of ET-1 in the carotid chemoreceptor system appears to be mainly due to a vasoconstrictor effect in the CB blood vessels. Â© 2005 Elsevier B.V. All rights reserved.
|Título según WOS:||Endothelins in the cat petrosal ganglion and carotid body: Effects and immunolocalization|
|Título según SCOPUS:||Endothelins in the cat petrosal ganglion and carotid body: Effects and immunolocalization|
|Título de la Revista:||BRAIN RESEARCH|
|Editorial:||ELSEVIER SCIENCE BV|
|Fecha de publicación:||2006|
|Página de inicio:||154|