In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes

Ahumada-Castro, Ulises; Bustos, Galdo; Silva-Pavez, Eduardo; Puebla-Huerta, Andrea; Lovy, Alenka; Cardenas, Cesar

Abstract

In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer.

Más información

Título según WOS: ID WOS:000629018000001 Not found in local WOS DB
Título de la Revista: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volumen: 9
Editorial: FRONTIERS MEDIA SA
Fecha de publicación: 2021
DOI:

10.3389/fcell.2021.629522

Notas: ISI