Ca2+ transfer to mitochondria: a spark of life in unexpected conditions

Silva-Pavez, Eduardo; Ahumada-Castro, Ulises; Lovy, Alenka; Cardenas, Julio Cesar

Abstract

The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative phosphorylation (OXPHOS). Here, we discuss how tumor mitochondria could become a feasible therapeutic target to treat tumors that depend on reductive carboxylation.

Más información

Título según WOS: ID WOS:000599422500001 Not found in local WOS DB
Título de la Revista: MOLECULAR CELLULAR ONCOLOGY
Volumen: 8
Número: 1
Editorial: TAYLOR & FRANCIS INC
Fecha de publicación: 2021
DOI:

10.1080/23723556.2020.1839341

Notas: ISI