Functional characterization of the ATPase-like activity displayed by a catalytic amyloid

Castillo-Caceres, Claudio; Duran-Meza, Eva; Nova, Esteban; Araya-Secchi, Raul; Monasterio, Octavio; Diaz-Espinoza, Rodrigo

Abstract

Background: Amyloids are highly ordered polypeptide aggregates stabilized by a beta-sheet structural core. Though classically associated to pathology, reports on novel functional roles of these proteins have increasingly emerged in the past decade. Moreover, the recent discovery that amyloids formed with rationally designed small peptides can exhibit catalytic reactivity has opened up new opportunities in both biology and biotechnology. The observed activities typically require the binding of divalent metals, giving rise to active metal-amyloid complexes.

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Título según WOS: Functional characterization of the ATPase-like activity displayed by a catalytic amyloid
Título de la Revista: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volumen: 1865
Número: 1
Editorial: ELSEVIER SCIENCE BV
Fecha de publicación: 2021
DOI:

10.1016/J.BBAGEN.2020.129729

Notas: ISI