The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction

Monteiro, Lara J.; Penailillo, Reyna; Sanchez, Mario; Acuna-Gallardo, Stephanie; Monckeberg, Max; Ong, Judith; Choolani, Mahesh; Illanes, Sebastian E.; Nardocci, Gino

Abstract

Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.

Más información

Título según WOS: The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction
Título de la Revista: GENES
Volumen: 12
Número: 7
Editorial: MDPI Open Access Publishing
Fecha de publicación: 2021
DOI:

10.3390/GENES12070970

Notas: ISI