Comparison of radionuclide ventriculography using SPECT and planar techniques in different cardiac conditions
Purpose: Accurate assessment of ventricular function is required to optimize therapeutic management of cardiac diseases. The aim of this study was to correlate planar equilibrium multigated acquisition (MUGA) with tomographic ventriculography (SPECT) in patients with diverse volumes and wall motion abnormalities. Methods: Eighty-three studies in 80 patients (56Â±14 years; 56% women) were classified according to ventricular dilation, wall motion abnormalities and systolic dysfunction. Left and right ventricular ejection fraction (LVEF and RVEF) and end-diastolic and end-systolic left ventricular volumes (EDV and ESV) were obtained using a commercial QBS program for SPECT. On planar acquisition, LVEF and RVEF were obtained using standard techniques and volumes were determined using the count-based method, without blood sampling. Results: A. Total group: With the planar method, LVEF was 44Â±17%, RVEF 42Â±13%, left EDV 147Â±97 ml (range 31-487 ml) and left ESV 93Â±85 ml (range 15-423 ml); with SPECT the corresponding values were 40Â±20%, 49Â±16%,131Â±95 ml and 91Â±89 ml, respectively (p=NS for all but RVEF). Linear correlation was 0.845 for LVEF, 0.688 for RVEF, 0.927 for left EDV and 0.94 for left ESV, with good intra-class correlation. B. Subgroups: Global and intra-class correlations between planar imaging and SPECT were high for volumes, RVEF and LVEF in all subgroups, except in patients with normal wall motion and function, who showed smaller volumes with SPECT. The group with diffuse wall motion abnormalities had a lower EDV on SPECT. In the abnormal left ventricle, RVEF was higher with SPECT. Conclusion: Good correlation and agreement exist between SPECT and planar MUGA with respect to LVEF and left ventricular volumes. SPECT is useful in patients with functional abnormalities, but less reliable in those with normal small cavities. A combined technique is still necessary, and RVEF should be interpreted cautiously. Â© 2007 Springer-Verlag.
|Título según WOS:||Comparison of radionuclide ventriculography using SPECT and planar techniques in different cardiac conditions|
|Título según SCOPUS:||Comparison of radionuclide ventriculography using SPECT and planar techniques in different cardiac conditions|
|Título de la Revista:||EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING|
|Fecha de publicación:||2007|
|Página de inicio:||1735|