Therapeutic Potential of Isoflavones with an Emphasis on Daidzein

Alshehri, Mohammed M.; Sharifi-Rad, Javad; Herrera-Bravo, Jesus; Jara, Evelyn L.; Salazar, Luis A.; Kregiel, Dorota; Uprety, Yadav; Akram, Muhammad; Iqbal, Mehwish; Martorell, Miquel; Torrens-Mas, Margalida; Pons, Daniel Gabriel; Dastan, Sevgi Durna; Cruz-Martins, Natalia; Ozdemir, Fethi Ahmet; et. al.


Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.

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Título según WOS: Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
Título de la Revista: Oxidative Medicine and Cellular Longevity
Volumen: 2021
Editorial: HINDAWI LTD
Fecha de publicación: 2021


Notas: ISI