Synthesis, structural, DNA/protein binding and cytotoxic studies of copper (I) proportional to-diimine hydrazone complexes

Gayathri, S.; Viswanathamurthi, P.; Thuslim, V; Sathya, M.; Ranjani, M.; Prabhakaran, R.; Haribabu, J.; Echeverria, Cesar

Abstract

A series of copper(I) complexes with alpha-diimine hydrazone ligands of the type [Cu(PPh3)(2)(L1-4)] (1-4) were synthesized by the reacting [Cu(CH3COO)(PPh3)(2)] with alpha-diimine ligands (L1-4) [L-1 = 1, 2-bis(2-(benzothiazole-2-yl)hydrazineylidene)-1, 2-dihydro acenaphthylene (AQBH), L-2 = 1, 2-bis(2-(quinolin-2-yl)hydrazineylidene)1, 2-dihydro acenaphthylene (AQQH), L-3 = 9, 10-bis(2-(benzothiazol-2-yl)dihydrazano)phenanthren-9,10-one (PQBH), L-4 = 9,10-bis(2-(quinolin-2-yl)dihydrazano)phenanthren-9(10H)-one (PQQH)]. The new complexes were characterized by elemental analysis, UV-vis, FT-IR, H-1 C-13 NMR spectra and electrospray ionization-mass spectrometry (ESI-MS). Especially, the solid state structure of L-1 (AQBH) was established using single crystal X-ray analysis. The interaction of complexes with CT-DNA was explored in detail using absorption and emission spectral methods to gain some insight into the structure-activity relationship. The obtained results revealed that complexes could interact with CT-DNA via intercalation. The interaction of these synthesized Cu (I) complexes with bovine serum albumin (BSA) was also evaluated using absorption and fluorescence techniques, which provided a static quenching mechanism between them. In addition, the cytotoxicity of compounds against HepG-2 (hepatic carcinoma) cancer and Vero normal (kidney epithelial cells extracted from an African green monkey) cells was evaluated by MTT assay. It was found that complex 4 (19.54 mu M) exhibited potential activity towards HepG-2 cells which was more efficient than cisplatin (48.50 mu M).

Más información

Título según WOS: Synthesis, structural, DNA/protein binding and cytotoxic studies of copper (I) proportional to-diimine hydrazone complexes
Título de la Revista: INORGANICA CHIMICA ACTA
Volumen: 533
Editorial: ELSEVIER SCIENCE SA LAUSANNE
Fecha de publicación: 2022
DOI:

10.1016/j.ica.2021.120780

Notas: ISI