Determination of five antimicrobial families in droppings of therapeutically treated broiler chicken by high-performance liquid chromatography-tandem mass spectrometry

Pokrant, Ekaterina; Trincado, Lina; Yevenes, Karina; Terraza, Gigliola; Maddaleno, Aldo; San Martin, Betty; Zavala, Sebastian; Hidalgo, Hector; Lapierre, Lisette; Cornejo, Javiera


Antimicrobials are currently used in poultry for disease treatment. However, their excretion in bird feces may contaminate the environment. Considering this, the objective of this work was to quantify antimicrobials residues concentrations in therapeutically treated broiler chicken droppings throughout the post-treatment period. For this aim a multiresidue method using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was validated. Forty-eight male broiler chickens were distributed and treated with commercial formulations of 5 different antimicrobials. Results showed that oxytetracycline and 4-epi-oxytetracycline, presented the highest concentrations during all sampling period, detecting concentrations of 1471.41 mu g kg(-1) at the last sampling point (day 22 post-treatment). Florfenicol, tylosin, enrofloxacin, and ciprofloxacin were eliminated and detected in treated chicken droppings until d 18 post-treatment. Sulfachloropyridazine decrease gradually during post-treatment period until day 30. Results demonstrate that studied antimicrobials in treated chicken droppings were eliminated for prolonged periods, therefore becoming a significant route of residues dissemination into the environment.

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Título según WOS: ID WOS:000688456700025 Not found in local WOS DB
Título de la Revista: POULTRY SCIENCE
Volumen: 100
Número: 9
Editorial: Elsevier
Fecha de publicación: 2021


Notas: ISI