5-HT2 Receptor Subfamily and the Halogen Bond Promise
The binding of C-4-halogenated 1-(4-X-2,5-dimethoxyphenyl)-2-aminopropane (DOX) serotonin agonist psychedelics at all three 5-HT2 receptor subtypes is up to two orders of magnitude stronger for X = Cl, Br, or I (but not F) than when C-4 bears a hydrogen atom and more than expected from their hydrophobicities. Our docking and molecular dynamics simulations agree with the fact that increasing the polarizability of halogens results in halogen-oxygen distances to specific backbone C=O groups, and C-X center dot center dot center dot O angles, in ranges expected for halogen bonds (XBs), which could contribute to the high affinities observed. Good linear correlations are found for each receptor type, indicating that the binding pocketl-igand affinity is enhanced as the XB interaction becomes stronger (i.e., I approximate to Br > Cl > F). It is also striking to note how the linear equations unveil that the receptor's response on the strength of the XB interaction is quite similar among 5-HT2A and 5-HT2C, whereas the 5-HT2B's sensitivity is less. The calculated dipole polarizabilities in the binding pocket of the receptors reflect the experimental affinity values, indicating that less-polarizable and harder binding sites are more prone to XB formation.
|Título según WOS:||5-HT2 Receptor Subfamily and the Halogen Bond Promise|
|Título de la Revista:||JOURNAL OF CHEMICAL INFORMATION AND MODELING|
|Editorial:||AMER CHEMICAL SOC|
|Fecha de publicación:||2021|
|Página de inicio:||5001|