INTEnsive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3): study protocol for a pragmatic stepped-wedge cluster-randomized controlled trial

Song, Lili; Hu, Xin; Ma, Lu; Chen, Xiaoying; Ouyang, Menglu; Billot, Laurent; Li, Qiang; Munoz-Venturelli, Paula; Abanto, Carlos; Pontes-Neto, Octavio Marques; Antonio, Arauz; Wasay, Mohammad; de Silva, Asita; Nguyen Huy Thang; Pandian, Jeyaraj Durai; et. al.

Abstract

Background: Early intensive blood pressure (BP) lowering remains the most promising treatment for acute intracerebral hemorrhage (ICH), despite discordant results between clinical trials and potential variation in the treatment effects by approach to control BP. As the third in a series of clinical trials on this topic, the INTEnsive care bundle with blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT3) aims to determine the effectiveness of a goal-directed care bundle protocol of early physiological control (intensive BP lowering, glycemic control, and pyrexia treatment) and reversal of anticoagulation, in acute ICH.

Más información

Título según WOS: INTEnsive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3): study protocol for a pragmatic stepped-wedge cluster-randomized controlled trial
Título de la Revista: TRIALS
Volumen: 22
Número: 1
Editorial: BMC
Fecha de publicación: 2021
DOI:

10.1186/S13063-021-05881-7

Notas: ISI