Nutrient cycling is an important mechanism for homeostasis in plant cells

Dreyer, Ingo


© American Society of Plant Biologists 2021. All rights reserved. For permissions, please email: journals.permissions@oup.comHomeostasis in living cells refers to the steady state of internal, physical, and chemical conditions. It is sustained by self-regulation of the dynamic cellular system. To gain insight into the homeostatic mechanisms that maintain cytosolic nutrient concentrations in plant cells within a homeostatic range, we performed computational cell biology experiments. We mathematically modeled membrane transporter systems and simulated their dynamics. Detailed analyses of 'what-if' scenarios demonstrated that a single transporter type for a nutrient, irrespective of whether it is a channel or a cotransporter, is not sufficient to calibrate a desired cytosolic concentration. A cell cannot flexibly react to different external conditions. Rather, at least two different transporter types for the same nutrient, which are energized differently, are required. The gain of flexibility in adjusting a cytosolic concentration was accompanied by the establishment of energy-consuming cycles at the membrane, suggesting that these putatively “futile” cycles are not as futile as they appear. Accounting for the complex interplay of transporter networks at the cellular level may help design strategies for increasing nutrient use efficiency of crop plants.

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Título según WOS: Nutrient cycling is an important mechanism for homeostasis in plant cells
Título de la Revista: PLANT PHYSIOLOGY
Volumen: 187
Número: 4
Fecha de publicación: 2021
Página de inicio: 2246
Página final: 2261


Notas: ISI