Relation between insulin resistance and breast cancer among Chilean women

Garmendia, ML; Pereira A.; Alvarado, ME; Atalah, E


Purpose: In Chile, diabetes and breast cancer are important public health problems. The association between insulin resistance and breast cancer, however, remains largely unexplored. Methods: We conducted a case-control study to assess the relationship of insulin resistance (IR) and breast cancer in Chilean premenopausal and postmenopausal women. We compared 170 women, 33 to 86 years old, with incident breast cancer and 170 normal mammography controls, matched by 5-year age interval. Plasmatic insulin and glucose were measured and IR was calculated by the homeostasis model assessment method. Anthropometric measurements and sociodemographic and behavioral data were also collected. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by multivariable conditional logistic regression. Results: IR was independently associated with breast cancer in postmenopausal women (OR = 2.70, 95%CI = 1.10-6.63), but not in premenopausal women (OR = 0.84, 95%CI = 0.20-3.52). Obesity was not associated with breast cancer at any age (OR = 0.68, 95%CI = 0.39-1.20). Conclusion: In this sample, IR increased the risk of breast cancer among postmenopausal women. © 2007 Elsevier Inc. All rights reserved.

Más información

Título según WOS: Relation between insulin resistance and breast cancer among Chilean women
Título según SCOPUS: Relation between Insulin Resistance and Breast Cancer among Chilean Women
Título de la Revista: ANNALS OF EPIDEMIOLOGY
Volumen: 17
Número: 6
Editorial: Elsevier Science Inc.
Fecha de publicación: 2007
Página de inicio: 403
Página final: 409
Idioma: English