Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component

Perez-Pastene, C; Graurnann, R; Diaz-Grez, F; Miranda, M; Venegas P.; Godoy, OT; Layson, L; Villagra R.; Matamala, JM; Herrera L.; Segura-Aguilar, J

Abstract

We have studied the association of a null mutation of Glutathione Transferase M1 (GST M1*0/0) with Parkinson's disease (MIM 168600) in a Chilean population with a strong Amerindian genetic component. We determined the genotype in 349 patients with idiopathic Parkinson's disease (174 female and 175 male; 66.84 ± 10.7 years of age), and compared that to 611 controls (457 female and 254 male; 62 ± 13.4 years of age). A significant association of the null mutation in GST M1 with Parkinson's disease was found (p = 0.021), and the association was strongest in the earlier age range. An association of GSTM1*0/0 with Parkinson's disease supports the hypothesis that Glutathione Transferase M1 plays a role in protecting astrocytes against toxic dopamine oxidative metabolism, and most likely by preventing toxic one-electron reduction of aminochrome. © 2007 Elsevier Ireland Ltd. All rights reserved.

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Título según WOS: Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component
Título según SCOPUS: Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component
Título de la Revista: NEUROSCIENCE LETTERS
Volumen: 418
Número: 2
Editorial: ELSEVIER SCI IRELAND LTD
Fecha de publicación: 2007
Página de inicio: 181
Página final: 185
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0304394007003187
DOI:

10.1016/j.neulet.2007.03.024

Notas: ISI, SCOPUS