Effects of interleukin-1 beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats

Arriagada, O.; Constandil, L; Hernandez A.; Barra, R; Soto-Moyano, R; Laurido C.

Abstract

To investigate the contribution of glial cells in the spinal cord nociceptive transmission, the effect of intrathecally administered interleukin-1β (IL-1β) was studied in rats treated with the glial cell inactivator propentofylline and submitted to a C-fiber-mediated reflex paradigm evoked by single and repetitive (wind-up) electric stimulation. Intrathecal IL-1β did not modify the C reflex integrated activity in either group of animals, while producing increased wind-up in intact and decreased wind-up in propentofylline pre-treated rats. Results suggest that the excitatory effect of IL-1β on spinal wind-up activity in healthy rats is produced by a glial mediator, whereas the inhibitory effect resulted from a direct effect of the cytokine on dorsal horn neurons. Copyright © 2007 Informa Healthcare.

Más información

Título según WOS: Effects of interleukin-1 beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats
Título según SCOPUS: Effects of interleukin-1ß on spinal cord nociceptive transmission in intact and propentofylline-treated rats
Título de la Revista: INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volumen: 117
Número: 5
Editorial: Informa Healthcare
Fecha de publicación: 2007
Página de inicio: 617
Página final: 625
Idioma: English
URL: http://informahealthcare.com/doi/abs/10.1080/00207450600773806
DOI:

10.1080/00207450600773806

Notas: ISI, SCOPUS