Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review

Hossain, Rajib; Quispe, Cristina; Herrera-Bravo, Jesus; Islam, Md. Shahazul; Sarkar, Chandan; Islam, Muhammad Torequl; Martorell, Miquel; Cruz-Martins, Natalia; Al-Harrasi, Ahmed; Al-Rawahi, Ahmed; Sharifi-Rad, Javad; Ibrayeva, Manshuk; Dastan, Sevgi Durna; Alshehri, Mohammed M.; Calina, Daniela; et. al.


Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, and Google Scholar using the keywords: "Lasia spinosa," then combined with "ethnopharmacological use," "phytochemistry," and "pharmacological activity." This updated review included studies with in vitro, ex vivo, and in vivo experiments with compounds of known concentration and highlighted pharmacological mechanisms. The research results showed that L. spinosa contains many important nutritional and phytochemical components such as alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, and volatile oil with excellent bioactivity. The importance of this review lies in the fact that scientific pharmacological evidence supports the fact that the plant has antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic, antidiabetic, antihyperlipidemic, and antinociceptive effects, while protecting the gastrointestinal system and reproductive. Regarding future toxicological and safety data, more research is needed, including studies on human subjects. In light of these data, L. spinosa can be considered a medicinal plant with effective bioactives for the adjuvant treatment of various diseases in humans.

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Título según WOS: Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review
Título de la Revista: Oxidative Medicine and Cellular Longevity
Volumen: 2021
Editorial: HINDAWI LTD
Fecha de publicación: 2021


Notas: ISI