A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Cruces, Pablo.; Retamal, Jaime.; Hurtado, Daniel E.; Erranz, Benjamin; Iturrieta, Pablo; Gonzalez, Carlos; Diaz, Franco


Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

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Título según WOS: ID WOS:000561438800002 Not found in local WOS DB
Título de la Revista: CRITICAL CARE
Volumen: 24
Número: 1
Editorial: BMC
Fecha de publicación: 2020


Notas: ISI