N-Arylation of 3-Formylquinolin-2(1H)-ones Using Copper(II)-Catalyzed Chan-Lam Coupling

Valencia, Jhesua; Sanchez-Velasco, Oriel A.; Saavedra-Olavarria, Jorge; Hermosilla-Ibanez, Patricio; Perez, Edwin G.; Insuasty, Daniel


3-formyl-2-quinolones have attracted the scientific community's attention because they are used as versatile building blocks in the synthesis of more complex compounds showing different and attractive biological activities. Using copper-catalyzed Chan-Lam coupling, we synthesized 32 new N-aryl-3-formyl-2-quinolone derivatives at 80 degrees C, in air and using inexpensive phenylboronic acids as arylating agents. 3-formyl-2-quinolones and substituted 3-formyl-2-quinolones can act as substrates, and among the products, the p-methyl derivative 9a was used as a substrate to obtain different derivatives such as alcohol, amine, nitrile, and chalcone.

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Título según WOS: ID WOS:000897348200001 Not found in local WOS DB
Título de la Revista: MOLECULES
Volumen: 27
Número: 23
Editorial: MDPI
Fecha de publicación: 2022


Notas: ISI