Abstract

A series of C-3,4,5-substituted 2,6-dimethyl-1,4-dihydropyridines (1,4-DHPs) with pharmacological properties were prepared by a variation from the classical Hantzsch synthesis. The procedure involves treatment of the respective aldehyde with either ethyl-3-aminocrotonate or 3-aminocrotonitrile in anhydrous acetic acid at temperatures not exceeding 60°C, thus minimizing by-product formation. The structures of title compounds were elucidated by 1H NMR, 13C NMR, FTIR, and elemental analysis. Copyright © Taylor & Francis Group, LLC.