Modulatory effects of histamine on cat carotid body chemoreception
Histamine has been proposed to be an excitatory transmitter between the carotid body (CB) chemoreceptor (glomus) cells and petrosal ganglion (PG) neurons. The histamine biosynthetic pathway, its storage and release, as well as the presence of histamine H1, H2 and H3 receptors have been found in the CB. However, there is only indirect evidence showing the presence of histamine in glomus cells, or weather its application produces chemosensory excitation. Thus, we studied the histamine immunocytochemical localization in the cat CB, and the effects of histamine, and H1, H2 and H3 receptor blockers on carotid sinus nerve (CSN) discharge, using CB and PG preparations in vitro. We found histamine immunoreactivity in dense-cored vesicles of glomus cells. Histamine induced dose-dependent increases in CSN discharge in the CB, but not in the PG. The H1-antagonist pyrilamine reduced the CB responses induced by histamine, the H2-antagonists cimetidine and ranitidine had no effect, while the H3-antagonist thioperamide enhanced histamine-induced responses. Present data suggests that histamine plays an excitatory modulatory role in the generation of cat CB chemosensory activity. Â© 2008 Elsevier B.V. All rights reserved.
|Título según WOS:||Modulatory effects of histamine on cat carotid body chemoreception|
|Título según SCOPUS:||Modulatory effects of histamine on cat carotid body chemoreception|
|Título de la Revista:||RESPIRATORY PHYSIOLOGY NEUROBIOLOGY|
|Editorial:||ELSEVIER SCIENCE BV|
|Fecha de publicación:||2008|
|Página de inicio:||401|