Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population

Camacho-Barcia, Lucia; Garcia-Gavilan, Jesus; Martinez-Gonzalez, Miguel angel; Fernandez-Aranda, Fernando; Galie, Serena; Corella, Dolores; Cuenca-Royo, Aida; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, angel M.; Warnberg, Julia; Martinez, J. Alfredo; Serra-Majem, Luis; Estruch, Ramon; Bernal-Lopez, M. Rosa; et. al.


Background In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests. Methods In 5,533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 +/- 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake. Results After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median [IQR]; 194.4 mu g/d [120.9, 373.1]) was inversely associated with a Mini-Mental State Examination (MMSE) score = 24 (OR [95% CI]; 0.53 [0.35, 0.79] P for trend = 0.002) compared with a decrease in the intake of vitamin K (median [IQR]; -97.8 mu g/d [-292.8, -51.5]). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR [95% CI]; 0.69 [0.51, 0.94] P for trend = 0.019) was found. Conclusions An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk.

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Título según WOS: ID WOS:000765909800010 Not found in local WOS DB
Título de la Revista: AGE AND AGEING
Volumen: 51
Número: 2
Fecha de publicación: 2022


Notas: ISI