Brain Vascular Dysfunction in Mothers and Their Children Exposed to Preeclampsia

Escudero, Carlos; Kupka, Ellen; Ibanez, Belen; Sandoval, Hermes; Troncoso, Felipe; Wikstroem, Anna-Karin; Lopez-Espindola, Daniela; Acurio, Jesenia; Torres-Vergara, Pablo; Bergman, Lina


Preeclampsia is a maternal syndrome characterized by the new onset of hypertension and proteinuria after 20 weeks of gestation associated with multisystemic complications, including brain alterations. Indeed, brain complications associated with preeclampsia are the leading direct causes of fetal and maternal morbidity and mortality, especially in low- and middle-income countries. In addition to the well-recognized long-term adverse cardiovascular effects of preeclampsia, women who have had preeclampsia have higher risk of stroke, dementia, intracerebral white matter lesions, epilepsy, and perhaps also cognitive decline postpartum. Furthermore, increasing evidence has also associated preeclampsia with similar cognitive and cerebral disorders in the offspring. However, the mechanistic links between these associations remain unresolved. This article summarizes the current knowledge about the cerebrovascular complications elicited by preeclampsia and the potential pathophysiological mechanisms involved, emphasizing the impaired brain vascular function in the mother and their offspring.

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Título según WOS: ID WOS:000917096300005 Not found in local WOS DB
Título de la Revista: HYPERTENSION
Volumen: 80
Número: 2
Fecha de publicación: 2023
Página de inicio: 242
Página final: 256


Notas: ISI