Fast and Simple Preparation of a Sensor Based on Electrochemically Reduced Graphene Oxide (rGO) for the Determination of Zopiclone in Pharmaceutical Dosage by Square Wave Adsorptive Stripping Voltammetry (SWAdSV)

Navarro, Freddy; Segura, Rodrigo; Godoy, Fernando; Marti, Angel A.; Mascayano, Carolina; Aguirre, Maria J.; Flores, Erick; Pizarro, Jaime

Abstract

The interactions of zopiclone with electrochemically reduced graphene oxide (rGO) modified electrode were examined. A comparison of GC/rGO and glassy carbon electrode (GC) by electrochemical impedance spectroscopy and scanning electrochemical microscopy (SECM) shows that the modified surface is much less conductive than GC. The role of rGO is to act as a site of specific adsorption of the analyte. Molecular dynamics showed that the monoanionic form of zopiclone presents more interactions with defects of rGO. The analytical methodology allowed obtaining a linearity of 10-130 mu g L-1, with a limit of detection of 2.14 mu g L-1 using SWAdSV at pH 10.0.

Más información

Título según WOS: ID WOS:000884440400001 Not found in local WOS DB
Título de la Revista: ELECTROANALYSIS
Volumen: 35
Número: 4
Editorial: WILEY-V C H VERLAG GMBH
Fecha de publicación: 2023
DOI:

10.1002/elan.202200357

Notas: ISI