PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications

Aguayo, Francisco; Perez-Dominguez, Francisco; Osorio, Julio C.; Oliva, Carolina; Calaf, Gloria M.


High-risk human papillomaviruses (HR-HPVs) are the causal agents of cervical, anogenital and a subset of head and neck carcinomas (HNCs). Indeed, oropharyngeal cancers are a type of HNC highly associated with HR-HPV infections and constitute a specific clinical entity. The oncogenic mechanism of HR-HPV involves E6/E7 oncoprotein overexpression for promoting cell immortalization and transformation, through the downregulation of p53 and pRB tumor suppressor proteins, among other cellular targets. Additionally, E6/E7 proteins are involved in promoting PI3K/AKT/mTOR signaling pathway alterations. In this review, we address the relationship between HR-HPV and PI3K/AKT/mTOR signaling pathway activation in HNC with an emphasis on its therapeutic importance.

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Título según WOS: ID WOS:000995522200001 Not found in local WOS DB
Título de la Revista: BIOLOGY-BASEL
Volumen: 12
Número: 5
Editorial: MDPI
Fecha de publicación: 2023


Notas: ISI