Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis
In previous work, we reported on the design of biodegradable rhein-loaded PLGA microparticles for the treatment of osteoarthritis. Considering that a formulation designed for intra-articular administration must meet sterility requirements to guarantee its safety, in this study the effect of gamma radiation sterilization on these microparticles was evaluated. The size, morphology, and surface characteristics of the micropar-ticles and the encapsulation efficiency of rhein were not affected by the sterilization process. Although DSC and PXRD analyses suggested otherwise, rhein release profiles were not altered by gamma radiation. The release of rhein from the microparticles was fitted to a Gompertz model. In conclusion, the results of this study suggest that gamma radiation is a suitable method for the sterilization of rhein-loaded PLGA micropar-ticles to enable their intra-articular administration in order to provide a therapeutic solution to patients suffering from chronic joint diseases.(c) 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.
|Título según WOS:
|ID WOS:000946677500001 Not found in local WOS DB
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|ID SCOPUS_ID:85141952639 Not found in local SCOPUS DB
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|JOURNAL OF PHARMACEUTICAL SCIENCES
|Elsevier Science Inc.
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