The IL-1 Family and Its Role in Atherosclerosis

Gonzalez, Leticia; Rivera, Katherine; Andia, Marcelo E.; Martinez Rodriguez, Gonzalo

Abstract

The IL-1 superfamily of cytokines is a central regulator of immunity and inflammation. The family is composed of 11 cytokines (with agonist, antagonist, and anti-inflammatory properties) and 10 receptors, all tightly regulated through decoy receptor, receptor antagonists, and signaling inhibitors. Inflammation not only is an important physiological response against infection and injury but also plays a central role in atherosclerosis development. Several clinical association studies along with experimental studies have implicated the IL-1 superfamily of cytokines and its receptors in the pathogenesis of cardiovascular disease. Here, we summarize the key features of the IL-1 family, its role in immunity and disease, and how it helps shape the development of atherosclerosis.

Más información

Título según WOS: ID WOS:000909393200001 Not found in local WOS DB
Título de la Revista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volumen: 24
Número: 1
Editorial: MDPI
Fecha de publicación: 2023
DOI:

10.3390/ijms24010017

Notas: ISI