Marlin-1 is expressed ion testis and associates to the cytoskeleton and GABA(B) receptors

Vidal, RL; Ramirez A.; Castro M.; Concha, II; couve, a

Abstract

Marlin-1 is a GABAB receptor and Jak tyrosine kinase-binding protein that also associates with RNA and microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression in lymphoid cells has also been reported. Here, we have studied the distribution of Marlin-1 in testis and spermatozoa. Our results indicate that Marlin-1 is highly expressed in testis. The protein is abundant in spermatogonia, spermatocytes, spermatozoa, and Sertoli cells. We also have studied the subcellular distribution in spermatozoa. Marlin-1 is present in the tail and to a lesser degree in the head of the sperm cell. Finally, we have explored two protein interactions. Our findings demonstrate that Marlin-1 associates with a microtubule fraction and with GABAB receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues. © 2007 Wiley-Liss, Inc.

Más información

Título según WOS: Marlin-1 is expressed ion testis and associates to the cytoskeleton and GABA(B) receptors
Título según SCOPUS: Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors
Título de la Revista: JOURNAL OF CELLULAR BIOCHEMISTRY
Volumen: 103
Número: 3
Editorial: Wiley
Fecha de publicación: 2008
Página de inicio: 886
Página final: 895
Idioma: English
URL: http://doi.wiley.com/10.1002/jcb.21456
DOI:

10.1002/jcb.21456

Notas: ISI, SCOPUS