Helicobacter pylori gastritis in children is associated with a regulatory T-cell response
Background & Aims: Helicobacter pylori infection in children infrequently causes gastroduodenal mucosal ulceration. Because H pylori induces T-cell dependent gastric inflammation in adults and T regulatory (Treg) cells suppress T-cell-dependent pathology, we evaluated gastric histopathology and Treg cell responses in H pylori-infected children and adults. Methods: Gastric tissue from 36 children and 79 adults with abdominal symptoms in Santiago, Chile, was evaluated prospectively for H pylori bacteria and histopathology using the Sydney classification and Treg responses using immunoassay, immunohistochemistry, and real-time polymerase chain reaction. Results: Eighteen (50%) of the children and 51 (65%) of the adults were infected with H pylori. Children and adults were colonized with similar levels of H pylori. However, the level of gastritis in the children was reduced substantially compared with that of the adults (P < .05). Coincident with reduced gastric inflammation, the number of Treg cells and levels of Treg cytokines (transforming growth factor [TGF]-Î²1 and interleukin-10) were increased markedly in the gastric mucosa of H pylori-infected children compared with that of infected adults (P < .03 and < .05, respectively). Also, H pylori infection in the children was associated with markedly increased levels of gastric TGF-Î²1 and interleukin-10 messenger RNA. Importantly, gastric TGF-Î²1 in H pylori-infected children localized predominantly to mucosal CD25+ and Foxp3+ cells, indicating a Treg source for the TGF-Î²1. Conclusions: Gastric pathology is reduced and local Treg cell responses are increased in H pylori-infected children compared with infected adults, suggesting that gastric Treg cell responses down-regulate the inflammation and ulceration induced by H pylori in children. Â© 2008 AGA Institute.
|Título según WOS:||Helicobacter pylori gastritis in children is associated with a regulatory T-cell response|
|Título según SCOPUS:||Helicobacter pylori Gastritis in Children Is Associated With a Regulatory T-Cell Response|
|Título de la Revista:||GASTROENTEROLOGY|
|Editorial:||W B SAUNDERS CO-ELSEVIER INC|
|Fecha de publicación:||2008|
|Página de inicio:||491|