Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues

VALDERRAMA, JA; Vásquez D.

Abstract

The preparation of two pyrimido[4,5-c]isoquinoline-7,10-quinones from acylhydroquinones and 1,3-dimethyl-5-aminouracil and their cycloadditions with 1-trimethylsilyloxybutadiene and 1-dimethylamino-3-methyl-1-azabutadiene is described. The remarkable regiocontrol of these cycloadditions that yield stable 1:1 cycloadducts is discussed on the basis of steric interactions into the pyrimido[4,5-c]isoquinoline-7,10-quinones. The access to angucyclinone AB-pyridopyrimidine analogues from Diels-Alder adducts and preliminar evidences on their antitumour activities are also reported. © 2007 Elsevier Ltd. All rights reserved.

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Título según WOS: Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues
Título según SCOPUS: Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues
Título de la Revista: TETRAHEDRON LETTERS
Volumen: 49
Número: 4
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2008
Página de inicio: 703
Página final: 706
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0040403907023386
DOI:

10.1016/j.tetlet.2007.11.133

Notas: ISI, SCOPUS