Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones

Vásquez D.; Rodriguez JA.; Theoduloz, C; Verrax J.; CALDERON, PB; VALDERRAMA, JA

Abstract

A series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives were prepared by regioselective amination reaction of pyrimido[4,5-c]isoquinoline-7,10-quinones with arylamines in the presence of a Lewis acid catalyst. Preliminary evaluation of the members of the series against cancer cell lines and assays of activation of their cytotoxic activity on K562 cells with ascorbic acid are reported. © 2009 Elsevier Ltd. All rights reserved.

Más información

Título según WOS: Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones
Título según SCOPUS: Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones
Título de la Revista: BIOORGANIC MEDICINAL CHEMISTRY LETTERS
Volumen: 19
Número: 17
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2009
Página de inicio: 5060
Página final: 5062
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0960894X09010063
DOI:

10.1016/j.bmcl.2009.07.041

Notas: ISI, SCOPUS