Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells

Burzio, VA; Villota, C; Villegas, J; Landerer, E.; Boccardo, E; Villa, LL; Martínez R.; López C.; Gaete, F; Toro V.; Rodríguez X; Burzio, LO

Abstract

We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.

Más información

Título según WOS: Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells
Título según SCOPUS: Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells
Título de la Revista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volumen: 106
Número: 23
Editorial: United States National Academy of Sciences
Fecha de publicación: 2009
Página de inicio: 9430
Página final: 9434
Idioma: English
URL: http://www.pnas.org/cgi/doi/10.1073/pnas.0903086106
DOI:

10.1073/pnas.0903086106

Notas: ISI, SCOPUS