Expression of voltage-activated calcium channels in the early zebrafish embryo

Sanhueza, D; Montoya A.; Sierralta, J; Kukuljan M.

Abstract

Summary Increases in cytosolic calcium concentrations regulate many cellular processes, including aspects of early development. Calcium release from intracellular stores and calcium entry through non-voltage-gated channels account for signalling in non-excitable cells, whereas voltage-gated calcium channels (CaV) are important in excitable cells. We report the expression of multiple transcripts of CaV, identified by its homology to other species, in the early embryo of the zebrafish, Danio rerio, at stages prior to the differentiation of excitable cells. CaV mRNAs and proteins were detected as early as the 2-cell stages, which indicate that they arise from both maternal and zygotic transcription. Exposure of embryos to pharmacological blockers of CaV does not perturb early development significantly, although late effects are appreciable. These results suggest that CaV may have a role in calcium homeostasis and control of cellular process during early embryonic development. © Cambridge University Press 2009.

Más información

Título según WOS: Expression of voltage-activated calcium channels in the early zebrafish embryo
Título según SCOPUS: Expression of voltage-activated calcium channels in the early zebrafish embryo
Título de la Revista: ZYGOTE
Volumen: 17
Número: 2
Editorial: CAMBRIDGE UNIV PRESS
Fecha de publicación: 2009
Página de inicio: 131
Página final: 135
Idioma: English
URL: http://www.journals.cambridge.org/abstract_S0967199408005108
DOI:

10.1017/S0967199408005108

Notas: ISI, SCOPUS