Studies on quinones. Part 45: Novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines

Valderrama, JA; Ibacache, JA; Arancibia, V; Rodriguez J.; Theoduloz, C

Abstract

A variety of 7-aminoisoquinoline-5,8-quinone derivatives were prepared from 2,5-dihydroxyacetophenone, methyl aminocrotonate, and the corresponding amines, through a highly efficient three-step sequence. The members of this series were tested on normal human fibroblasts and on a panel of three human cancer cell lines and their redox properties were determined by cyclic voltammetry in acetonitrile. Both the cytotoxicity and antitumor activity of 7-phenylaminoisoquinoline-5,8-quinone derivatives showed correlation with their half wave potentials and lipophilicities. © 2009 Elsevier Ltd. All rights reserved.

Más información

Título según WOS: Studies on quinones. Part 45: Novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines
Título según SCOPUS: Studies on quinones. Part 45: Novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines
Título de la Revista: BIOORGANIC & MEDICINAL CHEMISTRY
Volumen: 17
Número: 7
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2009
Página de inicio: 2894
Página final: 2901
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0968089609001497
DOI:

10.1016/j.bmc.2009.02.013

Notas: ISI, SCOPUS