Effect of Dietary Intake on the Levels of Biliary Unsaturated Free Fatty Acids Having Inhibitory Activity on Mutagens

Serra, I.; Tsuchiya Y.; Hori, Y; Nakamura K.; Villegas, R; Oyama, M; Makiguchi, T; Yamamoto M.

Abstract

Unsaturated free fatty acids (FFAs), such as palmitoleic, oleic, linoleic, linolenic and arachidonic acids, have inhibitory actions on mutagenesis. These FFAs in bile may play a role in preventing cholecystopathy and their levels may be influenced by diet. However, the effects of dietary intake on biliary FFAs levels is not known. In order to examine possible associations between dietary habits and biliary FFAs levels, bile samples were collected from resected gallbladders of 114 Chilean female patients with gallstones, and FFAs were measured with an HPLC system. The long-term dietary intake of the patients was investigated through a semi-quantitative food frequency questionnaire. A high intake of vegetables was negatively correlated with the total FFA level (r = -0.264, P = 0.010). Positive correlations were found between fruit consumption and the lauric acid level (r = 0.200, P = 0.041), fish consumption and the levels of oleic (r = 0.370, P <0.0001), linolenic (r = 0.197, P = 0.038) and arachidonic (r = 0.200, P =0.035) acids, and consumption of foods fried in vegetable oil and the linoleic acid level (r = 0.269, P =0.004). Linoleic, linolenic, and arachidonic acids which may have an inhibitory effect on actions of unknown mutagens in bile appear to be increased by consumption of high levels of fish and fried foods.

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Título según WOS: Effect of Dietary Intake on the Levels of Biliary Unsaturated Free Fatty Acids Having Inhibitory Activity on Mutagens
Título según SCOPUS: Effect of dietary intake on the levels of biliary unsaturated free fatty acids having inhibitory activity on mutagens
Título de la Revista: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
Volumen: 10
Número: 5
Editorial: ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
Fecha de publicación: 2009
Página de inicio: 899
Página final: 902
Idioma: English
Notas: ISI, SCOPUS