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Romina Paola Bertinat

Technician

Universidad de Concepcion

Concepción, Chile

Líneas de Investigación


Diabetes; Resistencia a insulina; Secreción glucagón por célula alfa pancreática; Fármacos anti-diabéticos; Gluconeogénesis hepatica y renal; Localización subcelular de enzimas metabólicas

Educación

  •  Biología celular y molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2010
  •  Bioquímico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2004

Experiencia Profesional

  •   Technician Part Time

    Universidad Austral de Chile

    Valdivia, Chile

    2003 - 2003

  •   Research assistant Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2003 - 2004

  •   Research assistant Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2010 - 2012

  •   Principal investigator Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2011 - 2014

  •   Management consultant Part Time

    Universidad de Concepcion

    Concepción, Chile

    2014 - 2015

  •   Technician Part Time

    Universidad de Concepcion

    Concepción, Chile

    2015 - 2015

  •   Associated researcher Part Time

    Universidad Austral de Chile

    Chile

    2015 - 2016

  •   Technician Part Time

    Universidad de Concepcion

    Concepción, Chile

    2015 - 2016

  •   Principal investigator Full Time

    Universidad de Concepcion

    Concepción, Chile

    2016 - 2019

  •   Technician Part Time

    Universidad de Concepcion

    Concepción, Chile

    2020 - 2021

  •   Technician Part Time

    Universidad de Concepcion

    Concepción, Chile

    2021 - A la fecha

Formación de Capital Humano


Undergraduate students

1. Marianne Negrón Mardones. "Study of the expression of PEPCK-C in rat pancreas". Medical Technologist Undergraduate, Universidad de Concepción. 2018. Tutor
2. Ahilyn Escobar Verdugo. "Study of the expression of mitochondrial PEPCK in different human and rat tissues". Medical Technologist Undergraduate, Universidad de Concepción. 2019. Tutor
3. Paula Marín del Valle. "Standardization of a simple protocol for purification of antibodies from egg yolk to advance in the study of diabetes". Medical Technologist Undergraduate, Universidad de Concepción. 2020. Tutor
4. Paula Díaz Cuevas y Camila González Acevedo. "Detección de niveles de expresión de PCK1 en células mononucleares de sangre periférica (PBMCs) por qPCR como biomarcador en el diagnóstico de resistencia a insulina". Medical Technologist Undergraduates, Universidad de Concepción. 2020. Tutor



 

Article (25)

Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients
Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients
Cytosolic phosphoenolpyruvate carboxykinase is expressed in alpha-cells from human and murine pancreas
Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice
Gluconeogenic Enzymes in beta-Cells: Pharmacological Targets for Improving Insulin Secretion
The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice
Aging Selectively Modulates Vitamin C Transporter Expression Patterns in the Kidney
Anti-Diabetic Agent Sodium Tungstate Induces the Secretion of Pro- and Anti-Inflammatory Cytokines by Human Kidney Cells
Apical Polarization of SVCT2 in Apical Radial Glial Cells and Progenitors During Brain Development
SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies
SGLT2 Inhibitors: Glucotoxicity and Tumorigenesis Downstream the Renal Proximal Tubule?
SVCT2 Overexpression in Neuroblastoma Cells Induces Cellular Branching that is Associated with ERK Signaling
In Vivo Sodium Tungstate Treatment Prevents E-Cadherin Loss Induced by Diabetic Serum in HK-2 Cell Line
Over-expression of muscle glycogen synthase in human diabetic nephropathy
Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney
Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development
Fructose 1,6-bisphosphatase and aldolase B location in organs of sheep supplemented with nonprotein nitrogen
Non-protein nitrogen supplementation increases gluconeogenic capacity in sheep
Nuclear accumulation of fructose 1,6-bisphosphatase is impaired in diabetic rat liver
Expression of key substrate cycle enzymes in rat spermatogenic cells: Fructose 1,6 bisphosphatase and 6 phosphofructose 1-kinase
Different involvement for aldolase isoenzymes in kidney glucose metabolism: Aldolase B but not aldolase a colocalizes and forms a complex with FBPase
Novel expression of liver FBPase in Langerhans islets of human and rat pancreas
Subcellular localization of liver FBPase is modulated by metabolic conditions
Broad expression of fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase provide evidence for gluconeogenesis in human tissues other than liver and kidney
Nuclear localization of liver FBPase isoenzyme in kidney and liver

Proyecto (11)

Role of mitochondrial dynamics in the oxidative stress-induced invasion in human prostate cancer cells
PHOSPHOENOLPYRUVATE CARBOXYKINASE EXPRESSION IN PANCREATIC ?-CELLS MODULATES GLUCAGON SECRETION, CONTRIBUTING TO HYPERGLUCAGONEMIA DURING DIABETES
CELLULAR POLARIZATION AND FUNCTIONAL ACTIVITY OF THE VITAMIN C TRANSPORTER,SVCT2,DURING CENTRAL NERVOUS SYSTEM DIFFERENTIATION (PRE- AND POST-NATAL) AND GLIOBLASTOMA PROGRESSION
IIIG9 EXPRESSION AND FUNCTION IN NORMAL EPENDYMAL CELLS DIFFERENTIATION AND TUMORAL TRANSFORMATION.
SODIUM TUNGSTATE A NEW TREATMENT FOR DIABETIC NEPHROPATHY=> EFFECT OF THIS DRUG IN INFLAMMATION, OXIDATIVE STRESS AND FIBROSIS DURING THE PROGRESSION OF THIS PATHOLOGY.
ESTUDIO DEL EFECTO DE WOLFRAMATO DE SODIO SOBRE LA FUNCION DEL RECEPTOR DE GLUCOCORTICOIDES EN LA PROGRESION DE NEFROPATIA DIABETICA
Producción de una vacuna oral contra piscirickettsia salmonis para disminuir la mortalidad en salmones y aumentar la competitividad y sustentabilidad de la industria salmonera
Study of nuclear translocation of human and rat fructose 1,6- bisphosphatase
ESTUDIO DE NUEVOS MECANISMOS DE REGULACION DE LA FRUCTOSA 1,6-BISFOSFATASA=> FORMACION DE COMPLEJOS METABOLICOS, COMPARTIMENTACION CELULAR Y UNION ASIMETRICA DEL SUSTRATO Y DEL EFECTOR FRUCTOSA-2,6-BISFOSFATO A LOS SITIOS ACTIVOS
RELACION DEL SINDROME DIABETICO CON LA EXPRESION Y LOCALIZACION CELULAR DE GLICOGENO SINTASA, FOSFOENOLPIRUVATO CARBOXIQUINASA Y FRUCTOSA-1, 6-BISFOSTASA, ENZIMAS CLAVES EN LA HOMEOSTASIS DE LA GLUCOSA
MODULACION DE LA FUNCION DE LA FRUCTOSA-1,6 BISFOSFATASA DE RINON DE CERDO=> EFECTO DE LIGANDOS SOBRE LA ESTRUCTURA, PLEGAMIENTO INTERACCION PROTEINA Y LOCALIZACION SUBCELULAR COMO MECANISMOS REGULADORES DE SU ACTIVIDAD

Review (1)

Sodium tungstate: Is it a safe option for a chronic disease setting, such as diabetes?
26
Romina Bertinat

Technician

Farmacología

Universidad de Concepcion

Concepción, Chile

19
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

10
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

4
Pamela Silva

Lab Manager

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

4
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

3
KATHERINE FORMAN

Profesor Asociado

nutrition and dietetics

universidad de concepción

concepción, Chile

2
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

1
Nery Jara

Profesor Asistente

Departamento de Farmacología

Universidad de Concepción

Concepción, Chile

1
Marcos Fernandez

Profesor Asociado

Farmacia

FACULTAD DE FARMACIA, UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
María Rauch

ACADEMICO

INSTITUTO DE BIOQUÍMICA Y MICROBIOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Pablo Torres

Profesor Asistente

Farmacia

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Juan Pontigo

Academico-Investigador

Medicina Veterinaria

Universidad San Sebastián

Puerto Montt, Chile

1
Ian Burbulis

Academic Professor Regular

Medicina

Universidad San Sebastian

Puerto Montt, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Francisca Espinoza

Investigadora postdoctoral

Facultad de Medicina

Universidad Católica de la Santisima Concepción

Concepción, Chile

1
Enrique Werner

Académico

Ciencias Básicas

UNIVERSIDAD DEL BIO-BIO

Chillán, Chile

1
Marcela Low

Docente Investigador

Facultad de Medicina y Ciencia

Universidad San Sebastián

Valdivia, Chile

1
Luciano Ferrada

Investigador

Biología celular

Universidad de Concepción

Concepcion, Chile