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JUAN PABLO RODRIGUEZ VIVES

FULL PROFESSOR

INTA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

The research interest of our laboratory has been focused on determining the role played by mesenchymal stem cells (MSCs) in the pathogenesis of postmenopausal osteoporosis.

CIENCIAS, BIOLOGIA, UNIVERSIDAD DE CHILE. Chile, 1991

FULL PROFESSOR Full Time

UNIVERSIDAD DE CHILE

INTA

Santiago, Chile

1981 - At present
Full Profesor Full Time

UNIVERSIDAD DE CHILE

INTA

Santiago, Chile

1981 - At present

FULL PROFESSOR Full Time

INTA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1981 - At present

Tutor of Postgraduate students (Thesis):
Carolina Figueroa A. Magister en Nutrición y Alimentos, m / Alimentos Saludables. INTA. U. de Chile
Melissa Miranda. Doctorado en Nutrición y Alimentos. Programa Interfacultades. U de Chile
Constanza Martínez. Doctorado en Ciencias, Mención Biología Celular, Molecular y Neurociencias. Fac. de Ciencias. U. de Chile
Pablo Astudillo. Magíster en Ciencias Biológicas. Facultad de Ciencias. U de Chile

Tutor of Undergraduate students (Thesis)
Consuelo Balanda. Odontología, Facultad de Odontología, Universidad de Chile
Celeste Avalos. Ingeniería en Biotecnología Molecular, Facultad de Ciencias. Universidad de Chile
César Navea. Bioquímica, USACH
Oscar Donoso. Bioquímica, Universidad Católica de Valparaíso
Andrea Flores. Ingeniería en Biotecnología Molecular, Facultad de Ciencias. Universidad de Chile.
Pablo Astudillo. Ingeniería en Biotecnología Molecular, Facultad de Ciencias.


Real-Time H2O2 Measurements in Bone Marrow Mesenchymal Stem Cells (MSCs) Show Increased Antioxidant Capacity in Cells From Osteoporotic Women Román F.; Urra C.; Porras O.; Pino A.M.; Rosen C.J.; Rodríguez J.P. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Unsaturation Level Decreased in Bone Marrow Fat of Postmenopausal Women with Low Bone Density Using High Resolution Magic Angle Spinning (HRMAS) 1H-NMR Spectroscopy Li X, Shet K, Xu K, Rodríguez JP, Pino AM, Kurhanewicz J, Schwartz A, Rosen CJ. Article ISI BONE (2017)
Characterization of Fatty Acid Composition in Bone Marrow Fluid From Postmenopausal Women: Modification After Hip Fracture Miranda M, Pino AM, Fuenzalida K, Rosen CJ, Seitz G, Rodríguez JP Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2016)
Osseointegration properties of titanium dental implants modified with a nanostructured coating based on ordered porous silica and bioactive glass nanoparticles. Covarrubias C, Mattmann M, Von Marttens A, Caviedes P, Arriagada C, Valenzuela F, Rodríguez JP, Corral C. Article APPLIED SURFACE SCIENCE (2016)
Qualitative aspects of Bone Marrow adiposity in osteoporosis Pino AM, Miranda M, Figueroa C, Rodríguez JP, Rosen CJ Article ISI SCOPUS FRONTIERS IN ENDOCRINOLOGY (2016)
Osteoporosis-associated alteration in the signalling status of BMP-2 in human MSCs under adipogenic conditions. Donoso O, Pino AM, Seitz G, Osses N, Rodríguez JP Article J Cell Biochem. (2015)
The Effect of the Nanoscale Structure of Nanobioceramics on their In Vitro Bioactivity and Cell Differentiation Properties. Covarrubias C, Arroyo F, Balanda C, Neira M, Von Marttens A, Caviedes P, Rodríguez JP, Urra C Article Journal of Nanomaterials (2015)
Synthesis of nanostructured porous silica coatings on titanium and their cell-adhesive and osteogenic differentiation properties Inzunza D, Covarrubias C, Von Marttensb A, Leighton Y, Carvajal JC, Valenzuela F, Díaz-Dosque M, Méndez N, Martínez C, Pino AM, Rodríguez JP, Smith P Article ISI Journal Biomedical Materials Research Part A (2013)
In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis Pino, Ana María; Rosen, Clifford J; Rodríguez, J. Pablo Article ISI SCIELO SCOPUS Biological Research (2012)
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells Xian L.; Wu X.; Pang L.; Lou, M; Rosen C.J.; Qiu T.; Crane, J.; Frassica F.; Zhang, L; Rodriguez, J. P.; Jia X; Yakar S.; Xuan S.; Efstratiadis A.; Wan, M; Cao, X Article ISI SCOPUS Nature Medicine (2012)
RELACION ENTRE GRASA Y EL HUESO: MECANISMO CLAVE EN LA OSTEOPOROSIS Rodriguez, Juan Article 1604-2004: SUPERNOVAE AS COSMOLOGICAL LIGHTHOUSES (2011)
Sonic Hedgehog stimulates Proliferation of Human Periodontal Stem Cells Martínez C, Rodríguez JP, Smith P, Palma V Article ISI JOURNAL OF DENTAL RESEARCH (2011)
Concentration of adipogenic and pro inflammatory cytokines in the bone marrow supernatant fluid of osteoporotic women Pino AM, Ríos S, Astudillo P, Fernández M, Figueroa P, Seitz G, Rodríguez JP Article ISI J Bone Min Res (2010)
Multiple myeloma bone marrow stromal cells characterize by increased expression of receptor activator of nuclear -B ligand (RANKL) which is inhibited by the bisphosphonate ibandronate Fernández M, Pino AM, Figueroa P, Rodríguez JP Article ISI J Cell Biochem. (2010)
Adipogenesis and osteoporosis Adipogénesis y osteoporosis Rodriguez, J. P.; Astudillo, P; Ríos S; Pino, A. M.; Seitz, G Article REVISTA MEDICA DE CHILE (2009)
Marrow Fat and the Bone Micro-Environment: Developmental, Functional and Pathological Implications Rosen CJ, Ackert-Bicknell C, Rodríguez JP, Pino AM Article ISI Crit Rev in Eukaryot Gene Expr (2009)
Increased adipogénesis of osteoporotic human-msenchymal stem cells (MSCs) characterizes by impaired leptin action Astudillo P, Ríos S, Pastenes L, Pino AM, Rodríguez JP Article ISI J Cell Biochem. (2008)
Aromatase activity of human mesenchymal stem cells is stimulated by early differentiation, vitamin D and leptin Pino AM, Rodríguez JM, Ríos S, Astudillo P, Leiva L, Seitz G, Fernández M, Rodríguez JP Article ISI J. Endocrinol (2006)
High affinity leptin receptors are present in human mesenchymal stem cells (MSCs) derived from control and osteoporotic donors Hess, R; Pino, AM.; Ríos S; Fernandez, M.; Rodriguez, JP Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2005)
CYTOSKELETAL ORGANIZATION OF HUMAN MESENCHYMAL STEM CELLS (MSC) CHANGES DURING THEIR OSTEOGENIC DIFFERENTIATION Ríos, Susana; Rodriguez, Juan; Pino, Ana; Gonzalez, Mauricio; Cambiazo, Liliana Article JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
DIFFERENTIAL ACTIVATION OF ERK1,2 MAP KINASE SIGNALING PATHWAY IN MESENCHYMAL STEM CELL FROM CONTROL AND OSTEOPOROTIC POSTMENOPAUSAL WOMEN Santibanez, Juan; Ríos, Susana; Rodriguez, Juan; Fernandez, Mireya Article MOLECULAR AND CELLULAR BIOCHEMISTRY (2004)
Modulation of the proliferation and differentiation of human stem cell s by copper Rodríguez JP, Ríos S, González M Article ISI J Cell Biochem. (2002)
Effects of zinc on cell proliferation and proteoglycan characteristics of epiphyseal chondrocytes Rodriguez, JP; Rosselot, G Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2001)
Sodium fluoride induce changes on proteoglycans synthesized by avian osteoblasts in culture Rodríguez JP, Rosselot G Article ISI J Cell Biochem. (2001)
Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring the adipogenic differentiation Rodríguez JP, Montecinos L, Ríos S, Reyes P, Martínez J Article ISI J Cell Biochem. (2000)
Abnormal osteogenesis in osteoporotic patients is reflected by altered Mesenchymal Stem Cells dynamics. Rodríguez JP, Garat S, Gajardo H, Pino AM, Seitz G Article ISI J Cell Biochem. (1999)
SOLUBLE FACTORS SECRETED BY PC-3 CELLS INDUCE STRUCTURAL CHANGES IN PROTEOGLYCANS PRODUCED BY FETAL RAT OSTEOBLASTS Santibanez, Juan; Rodriguez, Juan; Martinez, Jorge Article TUMOR BIOLOGY (1998)
Dermatan sulfate proteoglycans from the mineralized matrix of the avian eggshell Carrino, D.A.; Rodriguez, J. P.; Caplan, A. I. Article Connective Tissue Research (1997)
Cellular basis of bone tissue development Bases celulares del desarrollo del tejido óseo Rosselot, G; Martinez, J.; Rodriguez, J. P. Article REVISTA MEDICA DE CHILE (1996)
Molecular aspects of osteogenic phenomena Aspectos moleculares del fenómeno osteogénico Martinez, J.; Rosselot, G; Rodriguez, J. P. Article REVISTA MEDICA DE CHILE (1996)
The avian eggshell extracellular matrix as a model for biomineralization Carrino, D.A.; Dennis, J.E.; Caplan, A. I.; Wu, T.-M.; Arias J.L.; Fernández M.S.; Rodriguez, J. P.; Fink, D.J.; Heuer, A.H. Article Connective Tissue Research (1996)


Mesenchymal Stem Cells (MSC) in Osteoporotic Patients Rodriguez, J. P. BookSection (2002)


Functional alterations in IGF-1, BMP-2 and Wnt signaling are distinctive of mesenchymal stem cells (MSCs) from the bone marrow of osteoporotic women Rodríguez, Juan P; Pino, Ana M. Proyecto (2013)
En la osteoporosis, los adipocitos de la médula ósea generan un microambiente que favorece la vía de diferenciación adipogénica. Rodríguez, Juan P.; Pino, Ana M.; Fernández, Mireya Proyecto (2009)
Rol protector de la leptina en la osteoporosis: Efecto sobre las células progenitoras mesenquimáticas humanas (MSCs). Rodríguez, Juan P.; Pino, Ana M.; Fernández, Mireya Proyecto (2005)
Disrupted relationship between the metabolic status and the differentiation potential in human osteoporotic mesenchymal stem cells (MSCs). Rodríguez, Juan P.; Pino, Ana M. Proyecto (0)


ADIPOGENESIS AND OSTEOPOROSIS Rodriguez, Juan; Astudillo, Pablo; Ríos, Susana; Pino, Ana Review REVISTA MEDICA DE CHILE (2009)
Adipogénesis y osteoporosis Rodriguez, Juan Pablo.; Astudillo, Pablo; Ríos, Susana; Seitz, German; Pino, Ana María Review SCIELO REVISTA MEDICA DE CHILE (2009)
Involvement of Adipogenic Potential of Human Bone Marrow Mesenchymal Stem Cells (MSCs) in Osteoporosis Rodriguez, JP; Astudillo, P; Ríos S; Pino, AM. Review ISI CURRENT STEM CELL RESEARCH & THERAPY (2008)