Man

SANDRO GONZALO HUENCHUGUALA PERALTA

Líneas de Investigación


- Mecanismos celulares y moleculares en la enfermedad de Parkinson. - Desarrollo de organoides dopaminérgicos como nuevo modelo in vitro de la enfermedad de Parkinson. - Efectos antienvejecimiento de factores secretados por células madres.

Educación

  •  Doctor en Ciencias Biomédicas, Univiersidad de Chile. Chile, 2014
  •  Tecnólogo Médico, Universidad Austral. Chile, 2003

Experiencia Académica

  •   Profesor Part time

    Universidad Diego Portales

    Santiago, Chile

    2014 - 2014

  •   Profesor Part time

    Universidad Bernardo O´Higgins

    Santiago, Chile

    2014 - 2014

  •   Profesor Hora Part Time

    Universidad San Sebastián

    Facultad de Ciencia

    Puerto Montt, Chile

    2017 - At present

Experiencia Profesional

  •   Tecnólogo Médico

    Servicio de Salud Metropolitano Central

    Santiago, Chile

    2003 - 2008

  •   Postdoctorado Full Time

    University of Texas Health Science Center at Houston

    Houston, Estados Unidos

    2015 - 2017


 

Article (9)

Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite)

SILVA, VICTOR D.A.; CUEVAS, CARLOS; MUÑOZ, PATRICIA; VILLA, MONICA; AHUMADA-CASTRO, ULISES; Huenchuguala, Sandro; SANTOS, CLEONICE C. DOS; ARAUJO, FILLIPE M. DE; FERREIRA, RAFAEL S; SILVA, VANESSA B. DA; SILVA, JULIANA H.C. E; SOARES, ÉRICA N.; VELOZO, EUDES S.; Segura-Aguilar, Juan; COSTA, SILVIA L.

Article ISI SCOPUS
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS  (2017)

The Importance of Mitophagy in Maintaining Mitochondrial Function in U373MG Cells. Bafilomycin A1 Restores Aminochrome-lnduced Mitochondrial Damage

Huenchuguala, Sandro; Muñoz, Patricia; Segura-Aguilar, Juan

Article ISI SCOPUS
ACS Chemical Neuroscience  (2017)

Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin

Briceño A.; Muñoz P; Brito P.; Huenchuguala, S; Segura-Aguilar, J; Paris I.B.

Article ISI SCOPUS
NEUROTOXICITY RESEARCH  (2016)

DT-diaphorase protects astrocytes from aminochrome-induced toxicity

Huenchuguala, S; Muñoz P; Graumann R; Paris, I; Segura-Aguilar, J

Article ISI SCOPUS
NEUROTOXICOLOGY  (2016)

DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity

Muñoz P; Cardenas, S; Huenchuguala, S; Briceño A.; Couve, E.; Paris, I; Segura-Aguilar, J

Article ISI SCOPUS
Toxicological Sciences  (2015)

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity

Cuevas, Carlos; Huenchuguala, Sandro; Muñoz, Patricia; Villa, Monica; Paris, Irmgard; Mannervik, Bengt; Segura-Aguilar, Juan

Article ISI SCOPUS
Neurotoxicity Research  (2015)

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction

Huenchuguala, S; Muñoz P; Zavala P.; Villa, M; Cuevas, C; Ahumada, U; Graumann R; Nore, BF; Couve, E.; Mannervik, B; Paris, I; Segura-Aguilar, J

Article ISI SCOPUS
AUTOPHAGY  (2014)

Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson's Disease

Muñoz P; Huenchuguala, S; Paris, I; Cuevas, C; Villa, M; Caviedes P.; Segura-Aguilar, J; Tizabi Y.

Article ISI SCOPUS
NEUROTOXICITY RESEARCH  (2012)

Autophagy Protects Against Aminochrome-Induced Cell Death in Substantia Nigra-Derived Cell Line

Paris, I; Muñoz P; Huenchuguala, S; Couve, E.; Sanders, LH; Greenamyre, JT; Caviedes P.; Segura-Aguilar, J

Article ISI SCOPUS
TOXICOLOGICAL SCIENCES  (2011)

Review (1)

Dopamine Oxidation and Autophagy

Muñoz P; Huenchuguala, S; Paris, I; Segura-Aguilar, J

Review ISI SCOPUS
Parkinson's Disease  (2012)

10
SANDRO HUENCHUGUALA

9
Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

3
Eduardo Couve

2
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

1
Sergio Cárdenas

Coordinador de Investigación e investigador

Centro de Ingeniería y desarrollo sostenible

Universidad Central de Chile

Santiago, Chile