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Rafael Melo Freire

Academico Investigador

Universidad Central de Chile

Santiago, Chile

Nanomaterials; Nanostructured Materials; Magnetic Nanoparticles; Biomedical applications; Sensing

Chemistry, UNIVERSIDADE FEDERAL DO CEARA. Brasil, 2010
Chemistry, UNIVERSIDADE FEDERAL DO CEARA. Brasil, 2012
Chemistry, UNIVERSIDADE FEDERAL DO CEARA. Brasil

PhD Student Full Time

UNIVERSIDADE FEDERAL DO CEARA

Fortaleza, Brasil

2012 - 2016
Visiting Scholar Full Time

UNIVERSITY OF MASSACHUSETTS AMHERST

Amherst, Estados Unidos

2014 - 2015
Master Student Full Time

UNIVERSIDADE FEDERAL DO CEARA

Fortaleza, Brasil

2010 - 2012
Profesor Part Time

Universidad Autónoma de Chile

Instituto de Ciencias Químicas Aplicadas

Santiago, Chile

2020 - 2021

Investigador Joven Part Time

USACH/CEDENNA

Santiago, Chile

2019 - At present
Investigador Full Time

Instituto de Investigaciones Agropecuarias

Santiago, Chile

2021 - 2023
Academico Investigador Full Time

Universidad Central de Chile

Chile

2023 - At present


Determination of Co2+ ions in blood samples: A multi-way sensing based on NH2-rich carbon quantum dots Oliveira, J. J. P.; Carneiro, S. V.; Cruz, A. A. C.; Fechine, L. M. U. D.; Michea, S.; Antunes, R. A.; Neto, M. L. A.; Moura, T. A.; Cesar, C. L.; Carvalho, H. F.; Paschoal, A. R.; Lopes, G. S.; Freire, R. M.; Fechine, P. B. A. Article ISI DYES AND PIGMENTS (2023)
Straightforward synthesis of monodisperse Co/Zn-based nanoparticles and their antifungal activities on Botrytis cinerea Freire, Rafael M. M.; Silva-Moreno, Evelyn; Robles-Kelly, Christian; Infante, Claudia D. D.; Denardin, Juliano C. C.; Michea, Sebastian Article ISI AIP ADVANCES (2023)
Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications Magne, Tais Monteiro; de Oliveira Vieira, Thamires; Alencar, Luciana Magalhaes Rebelo; Maia Junior, Francisco Francine; Gemini-Piperni, Sara; Carneiro, Samuel V.; Fechine, Lillian M. U. D.; Freire, Rafael M.; Golokhvast, Kirill; Metrangolo, Pierangelo; Fechine, Pierre B. A.; Santos-Oliveira, Ralph Article ISI JOURNAL OF NANOSTRUCTURE IN CHEMISTRY (2022)
Magnetic FeM (M = Ag, Co, Cu, and Ni) nanocrystals as electrocatalysts for hydrogen evolution reaction Freire T.M.; Freire, R. M.; Franco, M. L.; Lopez, E. O.; De Oliveira, R. C.; Denardin, J.C.; Oliveria, F. G. S.; Vasconcelos, I. F.; Casciano, P. N. S.; De Lima -Neto, P.; Santos-Oliveira, R.; Fechine, P. B. A. Article MATERIALS TODAY SUSTAINABILITY (2022)
Silica Nanoparticles Modified with Fluorescent Dyes as Probes for in Situ Characterization of Natural Rubber Coatings Oliveira, Naiara C.; Paula, Amauri J.; Maia, Marcella T.; Noronha, Victor T.; Alves, Ana C.; Freire, Rafael M.; Filho, Antonio G. Souza; Ferreira, Odair P.; Faria, Andreia F.; do Nascimento, Rodney M. Article ISI ACS APPLIED NANO MATERIALS (2022)
A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent Neto, Davino M. A.; da Costa, Luelc S.; de Menezes, Fernando L.; Fechine, Lillian M. U. D.; Freire, Rafael M.; Denardin, Juliano C.; Banobre-Lopez, Manuel; Vasconcelos, Igor F.; Ribeiro, Thiago S.; Leal, Luzia Kalyne A. M.; de Sousa, Joao A. C.; Gallo, Juan; Fechine, Pierre B. A. Article ISI APPLIED SURFACE SCIENCE (2021)
Coercivity dependence of cation distribution in Co-based spinel: correlating theory and experiments Freire, R. M.; Palma, J. L.; Michea, S.; Ramirez, R.; Baltazar, S. E.; Denardin, J. C. Article ISI INORGANIC CHEMISTRY FRONTIERS (2021)
Highly sensitive sensing of food additives based on fluorescent carbon quantum dots Carneiro, S., V; Holanda, M. H. B.; Cunha, H. O.; Oliveira, J. J. P.; Pontes, S. M. A.; Cruz, A. A. C.; Fechine, L. M. U. D.; Moura, T. A.; Paschoal, A. R.; Zambelli, R. A.; Freire, R. M.; Fechine, P. B. A. Article ISI JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2021)
Hydroxyapatite-Based Magnetic Bionanocomposite as Pharmaceuticals Carriers in Chitosan Scaffolds Chaves, Anderson Valerio; Freire, Rafael Melo; Feitosa, Victor Pinheiro; Ricardo, Nagila Maria Pontes Silva; Denardin, Juliano Casagrande; Andrade Neto, Davino Machado; Fechine, Pierre Basilio Almeida Article ISI JOURNAL OF COMPOSITES SCIENCE (2021)
New nanocomposite made of cashew apple bagasse lignin and Fe3O4 for immobilizing of lipase B from Candida antarctica aiming at esterification Serpa, Juliana de Franca; Matias, Gabriel A. B.; Fechine, Pierre B. A.; da Costa, Victor M.; Freire, Rafael M.; Denardin, Juliano C.; Goncalves, Luciana R. B.; de Macedo, Andre C.; Rocha, Maria V. P. Article ISI JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2021)
Organophosphorus halloysite nanotubes as adsorbent for lead preconcentration in wine and grape juice Santana, Allan M.; Freire, Tiago M.; da Silva, Francisco L. F.; Menezes, Fernando L.; Ramos, Lauren L.; Cavalcante, Giovanna R.; Fechine, Lillian M. U. D.; Vieira, Lais H. S.; Ferreira, Odair P.; Freire, Rafael M.; Denardin, Juliano C.; Lopes, Gisele S.; Matos, Wladiana O.; Fechine, Pierre B. A. Article ISI APPLIED CLAY SCIENCE (2021)
Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy ALEXANDRE C.C. SOUSA; ADOLFO I.B. ROMO; RAIMUNDO R. ALMEIDA; AIERTA C.C. SILVA; LILLIAN M.U. FECHINE; DEBORA H.A. BRITO; RAFAEL M. FREIRE; DANIEL P. PINHEIRO; LARISSA M. R. SILVA; OTÍLIA D.L. PESSOA; JULIANO C. DENARDIN; CLAUDIA PESSOA; NAGILA M.P.S. Ricardo Article CARBOHYDRATE POLYMERS (2021)
Structural, morphological and magnetic properties of iron oxide thin films obtained by atomic layer deposition as a function of their thickness Marquez, Paulina; Alburquenque, Daniela; Celis, Freddy; Freire, Rafael Melo; Escrig, Juan Article JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS (2021)
From Magneto-Dielectric Biocomposite Films to Microstrip Antenna Devices de Menezes, Fernando Lima; Andrade Neto, Davino Machado; Rodrigues, Maria do Livramento Linhares; Lima, Helder Levi Silva; Paiva, Denis Valony Martins; da Silva, Marcelo Antônio Santos; Fechine, Lillian Maria Uchôa Dutra; Sombra, Antônio Sérgio Bezerra; Freire, Rafael Melo; Denardin, Juliano Casagrande; Rosa, Morsyleide de Freitas; de Souza Filho, Men de Sá Moreira; Mazzetto, Selma Elaine; Fechine, Pierre Basílio Almeida Article JOURNAL OF COMPOSITES SCIENCE (2020)
Lipase FromRhizomucor mieheiImmobilized on Magnetic Nanoparticles: Performance in Fatty Acid Ethyl Ester (FAEE) Optimized Production by the Taguchi Method Moreira, Katerine S.; de Oliveira, Andre L. B.; Junior, Lourembergue S. de M.; Monteiro, Rodolpho R. C.; Rocha, Thays N.; Menezes, Fernando L.; Fechine, Lillian M. U. D.; Denardin, Juliano C.; Michea, Sebastian; Freire, Rafael M.; Fechine, Pierre B. A.; Souza, Maria C. M.; dos Santos, Jose C. S. Article ISI FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)
Magnetic Porous Controlled Fe3O4-Chitosan Nanostructure: An Ecofriendly Adsorbent for Efficient Removal of Azo Dyes Freire, Tiago M.; Fechine, Lillian M. U. D.; Queiroz, Danilo C.; Freire, Rafael M.; Denardin, Juliano C.; Ricardo, Nagila M. P. S.; Rodrigues, Thaina N. B.; Gondim, Diego R.; Junior, Ivanildo J. S.; Fechine, Pierre B. A. Article ISI NANOMATERIALS (2020)
Natural arrangement of AgCu bimetallic nanostructures through Oleylamine reduction Freire, Rafael; Rojas-Nunez, Javier; Elías, Ana Laura; Fujisawa, Kazunori; Troncoso, Loreto; Denardin, Juliano; Baltazar, Samuel E. Article INORGANIC CHEMISTRY FRONTIERS (2020)
Carneiro Cruz, A. A., Freire, R. M., Froelich, D. B., Alves de Lima, A. C., Muniz, A. R., Ferreira, O. P., & Fechine, P. B. A. (2019). Fluorescence Based Platform to Discriminate Protein Using Carbon Quantum Dots Carneiro Cruz, A. A.; Freire, R. M.; Froelich, D. B.; Alves de Lima, A. C.; Muniz, A. R.; Ferreira, O. P.; & Fechine, P. B. A. Article ChemistrySelect (2019)
Electrodeposition of 1-D tellurium nanostructure on gold surface from choline chloride-urea and choline chloride-ethylene glycol mixtures Luis P.M. dos Santos, Rafael M. Freire; Sebastian Michea, Juliano C. Denardin; Daniel B. Araújo, Eduardo B. Barros; Adriana N. Correia, Pedro de Lima-Neto Article JOURNAL OF MOLECULAR LIQUIDS (2019)
Fluorescence Based Platform to Discriminate Protein Using Carbon Quantum Dots Carneiro?Cruz, Antônio Alvernes; Freire, Rafael Melo; Froelich, Diese Beatiz; Alves?de?Lima, Ari Clesius; Muniz, André Rodrigues; Ferreira, Odair Pastor; Fechine, Pierre Basílio Almeida Article ISI SCOPUS CHEMISTRYSELECT (2019)
Probing the Defect-Induced Magnetocaloric Effect on Ferrite/Graphene Functional Nanocomposites and their Magnetic Hyperthermia Prabhakaran, T.; Udayabhaskar, R.; Mangalaraja, R. V.; Sahlevani, Saeed Farhang; Freire, Rafael M.; Denardin, Juliano C.; Beron, F.; Varaprasad, Kokkarachedu; Angel Gracia-Pinilla, Miguel; Vinicius-Araujo, Marcus; Bakuzis, Andris F. Article ISI SCOPUS JOURNAL OF PHYSICAL CHEMISTRY C (2019)
Sensing strategy based on Carbon Quantum Dots obtained from riboflavin for the identification of pesticides Carneiro S.V.; de Queiroz V.H.R.; Cruz A.A.C.; Fechine L.M.U.D.; Denardin J.C.; Freire R.M.; do Nascimento R.F.; Fechine P.B.A. Article ISI SCOPUS SENSORS AND ACTUATORS B-CHEMICAL (2019)
Nanocrystal growth, magnetic and electrochemical properties of NiZn ferrite FREITAS, P.G.C. ; GALVAO, W.S. ; COSTA, L.S. ; RIBEIRO, T.S. ; VASCONCELOS, I.F. ; DENARDIN, J.C. ; DE OLIVEIRA, R.C. ; SOUSA, C.P. ; DE-LIMA-NETO, P. ; CORREIA, A.N. ; FECHINE, P.B.A. Article JOURNAL OF ALLOYS AND COMPOUNDS (2018)
NH2-rich Carbon Quantum Dots=> A protein-responsive probe for detection and identification FREIRE, R.M.; LE, NGOC D.B. ; JIANG, ZIWEN ; KIM, CHANG SOO ; ROTELLO, VINCENT M. ; FECHINE, P.B.A. Article Sensors and Actuators B=> Chemical (2018)
Ultrafast sonochemistry-based approach to coat TiO 2 commercial particles for sunscreen formulation BARBOSA, J.S. ; NETO, D.M.A. ; FREIRE, R.M. ; ROCHA, J.S. ; FECHINE, L.M.U.D. ; DENARDIN, J.C. ; VALENTINI, A. ; DE ARAÚJO, T.G. ; MAZZETTO, S.E. ; FECHINE, P.B.A. Article ULTRASONICS SONOCHEMISTRY (2018)
Carbon Quantum Dots=> A Safe Tool to Learn about Quantum Phenomenon in Nanomaterials CRUZ, A. A. C. ; FREIRE, R. M. ; CARNEIRO, S. V. ; FERREIRA, O. P. ; Fechine, P. B. A. Article Journal of Laboratory Chemical Education (2017)
Production of flavor esters catalyzed by lipase B from Candida antarctica immobilized on magnetic nanoparticles SOUZA, M. C. M. DE ; SANTOS, K. P. DOS ; FREIRE, R. M. ; BARRETO, A. C. H. ; FECHINE, P. B. A. ; GONÇALVES, L. R. B. Article BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING (ONLINE) (2017)
Rapid Sonochemical Approach Produces Functionalized Fe 3 O 4 Nanoparticles with Excellent Magnetic, Colloidal, and Relaxivity Properties for MRI Application NETO, DAVINO M. A. ; Freire, Rafael M. ; GALLO, JUAN ; Freire, Tiago M. ; QUEIROZ, DANILO C. ; RICARDO, NÁGILA M. P. S. ; VASCONCELOS, IGOR F. ; MELE, GIUSEPPE ; CARBONE, LUIGI ; MAZZETTO, SELMA E. ; BAÑOBRE-LÓPEZ, MANUEL ; FECHINE, PIERRE B. A. Article JOURNAL OF PHYSICAL CHEMISTRY C (2017)
Super-paramagnetic Nanoparticles with Spinel Structure: A Review of Synthesis and Biomedical Applications Galvao, W. S. ; Andrade Neto, D. M. ; Freire, R. M. ; Fechine, P. B. A. Article Solid State Phenomena (2016)
New magnetic nanobiocomposite based in galactomannan/glycerol and superparamagnetic nanoparticles Souza, N.D.G.; Freire, R.M.; Cunha, A.P.; da Silva, M.A.S.; Mazzetto, S.E.; Sombra, A.S.B.; Denardin, J.C.; Ricardo, N.M.P.S.; Fechine, P.B.A. Article Materials Chemistry and Physics (2015)
Cubic superparamagnetic nanoparticles of NiFe2O4 via fast microwave heating Galvao, WS; Freire, RM; Ribeiro, TS; Vasconcelos, IF; Costa, LS; Freire, VN; Sales, FAM; Denardin, JC; Fechine, PBA Article JOURNAL OF NANOPARTICLE RESEARCH (2014)
Effect of solvent composition on the structural and magnetic properties of MnZn ferrite nanoparticles obtained by hydrothermal synthesis Freire, RM; Freitas, PGC; Ribeiro, TS; Vasconcelos, IF; Denardin, JC; Mele, G; Carbone, L; Mazzetto, SE; Fechine, PBA Article MICROFLUIDICS AND NANOFLUIDICS (2014)
Grain Size Control of the Magnetic Nanoparticles by Solid State Route Modification. Journal of Materials Engineering and Performance Barreto, A. C. H. ; Santiago, V. R. ; Freire, R. M. ; Mazzetto, S. E. ; Sasaki, J. M. ; Vasconcelos, I. F. ; Denardin, J. C. ; Mele, Giuseppe; Carbone, Luigi ; Fechine, P. B. A. Article JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE (2013)
Magnetic nanosystem for cancer therapy using oncocalyxone a, an antitomour secondary metabolite isolated from a Brazilian plant. Barreto, Antônio C H; Santiago, Vivian R; Freire, Rafael M; Mazzetto, Selma E; Denardin, Juliano C; Mele, Giuseppe; Cavalcante, Igor M; Ribeiro, Maria E N P; Ricardo, Nágila M P S; Gonçalves, Tamara; Carbone, Luigi; Lemos, Telma L G; Pessoa, Otília D L; Fechine, Pierre B A Article International journal of molecular sciences (2013)
MZnFe2O4 (M = Ni, Mn) cubic superparamagnetic nanoparticles obtained by hydrothermal synthesis Freire, RM; Ribeiro, TS; Vasconcelos, IF; Denardin, JC; Barros, EB; Mele, G; Carbone, L; Mazzetto, SE; Fechine, PBA Article JOURNAL OF NANOPARTICLE RESEARCH (2013)
Nanotechnology in Hormone Replacement Therapy: Safe and Efficacy of Transdermal Estriol and Estradiol Nanoparticles after 5 Years Follow-Up Study Gonzaga, L. W. ; Botelho, M. A. ; Queiroz, D. B. ; Fechine, P. B. A. ; Freire, R. M. ; Azevedo, E. ; Morais, A. ; Ruela, R. S. ; Lyra, A. ; Gomes, S. ; Quintans JR, L Article Latin American Journal of Pharmacy (2012)
High catalytic activity of nitrogen-containing carbon from molecular sieves in fine chemistry Batista, A. H. M. ; Freire, R. M. ; Souza Filho, A. G. ; Filho, J. M. ; Saraiva, G. D. ; Oliveira, A. C. Article CATALYSIS LETTERS (2009)
Studies of catalytic activity and coke deactivation of spinel oxides during ethylbenzene dehydrogenation Freire, R. M.; de Sousa, Francisco F. ; Pinheiro, Anderson L. ; Longhinotti, Elisane ; Filho, J. Mendes ; Oliveira, Alcemira C. ; Freire, Paulo de Tarso C. ; Ayala, Alejandro P. ; Oliveira, Oliveira A.C. Article APPLIED CATALYSIS A-GENERAL (2009)


Development of a new multimodal magnetic platform for Theranostic Freire, Rafael Melo Proyecto (2017)
DEVELOPMENT OF A NEW MULTIMODAL MAGNETIC PLATFORM FOR THERANOSTIC FONDECYT (3170240) Proyecto 2017-2020 Inv. Responsable