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Daniel Eduardo Carvajal Hausdorf

Patólogo Staff

Clínica Alemana - Facultad de Medicina Universidad del Desarrollo

Santiago, Chile

Biomarcadores moleculares. Cáncer de mama. Cáncer de pulmón. Cáncer de vesícula biliar. Análisis de imágenes. Métodos objetivos de análisis.

Médico-Cirujano, UNIVERSIDAD DE CHILE. Chile, 2008
Médico Especialista en Anatomía Patológica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012

Postdoctoral Associate Full Time

YALE UNIVERSITY

New Haven, CT, Chile

2012 - 2017
Profesor Investigador Asistente Adjunto Other

UNIVERSIDAD DEL DESARROLLO

Facultad de Medicina Clinica Alemana Universidad del Desarrollo

Santiago, Chile

2022 - At present

Doctoral Thesis: IL-11 and OSM promote tumor progression in TP53-mutated hormone receptor-positive breast cancer. Carla Araya, PhD (c), Doctorado en Ciencias e Innovación en Medicina, Facultad de Medicina Clinica Alemana Universidad del Desarrollo, Chile

Undergraduate Thesis: Clinical significance of the activation of signal transduction pathways in metastatic hormone receptor-positive breast cancer. Felipe Nahuelñir, School of Biochemistry, Universidad de Santiago, Chile.


Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC) Carvajal-Hausdorf, D; Altan, M; Velcheti, V; Gettinger, SN; Herbst, RS; Rimm, DL; Schalper, KA Article ISI SCOPUS Journal for ImmunoTherapy of Cancer (2019)
Immune Checkpoint Inhibitor-Associated Pericarditis Altan, Mehmet; Toki, Maria I.; Gettinger, Scott N.; Carvajal-Hausdorf, Daniel E.; Zugazagoitia, Jon; Sinard, John H.; Herbst, Roy S.; Rimm, David L. Article ISI SCOPUS JOURNAL OF THORACIC ONCOLOGY (2019)
Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry Carvajal-Hausdorf, Daniel E.; Patsenker, Jonathan; Stanton, Kelly P.; Villarroel-Espindola, Franz; Esch, Amanda; Montgomery, Ruth R.; Psyrri, Amanda; Kalogeras, Konstantine T.; Kotoula, Vassiliki; Foutzilas, George; Schalper, Kurt A.; Kluger, Yuval; Rimm, David L. Article ISI SCOPUS CLINICAL CANCER RESEARCH (2019)
An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients Moore, Lauren M.; Wilkinson, Rachel; Altan, Mehmet; Toki, Maria; Carvajal-Hausdorf, Daniel E.; McGuire, John; Ehrlich, Barbara E.; Rimm, David L. Article npj Breast Cancer (2018)
Association of B7-H4, PD-L1, and tumor infiltrating lymphocytes with outcomes in breast cancer Altan M, Kidwell KM, Pelekanou V, Carvajal-Hausdorf DE, Schalper KA, Toki MI, Thomas DG, Sabel MS, Hayes DF, Rimm DL Article NPJ Breast Cancer (2018)
Laparoscopic management of incidental gallbladder cancer de Aretxabala, X; Oppliger, F; Solano, N; Rencoret G.; Vivanco M.; Carvajal, D; Hepp, J; Roa, I Article ISI SCOPUS SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2018)
Macrodissection prior to closed system RT-qPCR is not necessary for estrogen receptor and HER2 concordance with IHC/FISH in breast cancer Gupta, Swati; Mani, Navin R.; Carvajal-Hausdorf, Daniel E.; Bossuyt, Veerle; Ho, Kenneth; Weidler, Jodi; Wong, Wendy; Rhees, Brian; Bates, Michael; Rimm, David L. Article ISI SCOPUS LABORATORY INVESTIGATION (2018)
Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer. Schalper, Kurt A; Carvajal-Hausdorf, Daniel; McLaughlin, Joseph; Altan, Mehmet; Velcheti, Vamsidhar; Gaule, Patricia; Sanmamed, Miguel F; Chen, Lieping; Herbst, Roy S; Rimm, David L Article Clinical cancer research => an official journal of the American Association for Cancer Research (2017)
Effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes and PD-L1 expression in breast cancer and its clinical significance Pelekanou, Vasiliki; Carvajal-Hausdorf, Daniel E.; Altan, Mehmet; Wasserman, Brad; Carvajal-Hausdorf, Cristobal; Wimberly, Hallie; Brown, Jason; Lannin, Donald; Pusztai, Lajos; Rimm, David L. Article ISI BREAST CANCER RESEARCH (2017)
High concordance of a closed-system, RT-qPCR breast cancer assay for HER2 mRNA, compared to clinically determined immunohistochemistry, fluorescence in situ hybridization, and quantitative immunofluorescence Wasserman, Brad E.; Carvajal-Hausdorf, Daniel E.; Ho, Kenneth; Wong, Wendy; Wu, Natalie; Chu, Victor C.; Lai, Edwin W.; Weidler, Jodi M.; Bates, Michael; Neumeister, Veronique; Rimm, David L. Article ISI LABORATORY INVESTIGATION (2017)
Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer Carvajal-Hausdorf, DE; Mani, N; Velcheti, V; Schalper, KA; Rimm, DL Article ISI SCOPUS Journal for ImmunoTherapy of Cancer (2017)
Objective, domain-specific HER2 measurement in uterine and ovarian serous carcinomas and its clinical significance. Carvajal-Hausdorf, Daniel E; Schalper, Kurt A; Bai, Yalai; Black, Jonathan; Santin, Alessandro D; Rimm, David L Article Gynecologic oncology (2017)
Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer. Rehman, Jamaal A; Han, Gang; Carvajal-Hausdorf, Daniel E; Wasserman, Brad E; Pelekanou, Vasiliki; Mani, Nikita L; McLaughlin, Joseph; Schalper, Kurt A; Rimm, David L Article Modern pathology => an official journal of the United States and Canadian Academy of Pathology, Inc (2017)
Automated measurement of estrogen receptor in breast cancer=> a comparison of fluorescent and chromogenic methods of measurement. Zarrella, Elizabeth R; Coulter, Madeline; Welsh, Allison W; Carvajal, Daniel E; Schalper, Kurt A; Harigopal, Malini; Rimm, David L; Neumeister, Veronique M Article Laboratory investigation; a journal of technical methods and pathology (2016)
EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma. Toki, Maria I; Carvajal-Hausdorf, Daniel E; Altan, Mehmet; McLaughlin, Joseph; Henick, Brian; Schalper, Kurt A; Syrigos, Konstantinos N; Rimm, David L Article Journal of thoracic oncology => official publication of the International Association for the Study of Lung Cancer (2016)
Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer. McLaughlin, Joseph; Han, Gang; Schalper, Kurt A; Carvajal-Hausdorf, Daniel; Pelekanou, Vasiliki; Rehman, Jamaal; Velcheti, Vamsidhar; Herbst, Roy; LoRusso, Patricia; Rimm, David L Article JAMA oncology (2016)
Measurement of Domain-Specific HER2 (ERBB2) Expression May Classify Benefit From Trastuzumab in Breast Cancer. Carvajal-Hausdorf, Daniel E; Schalper, Kurt A; Pusztai, Lajos; Psyrri, Amanda; Kalogeras, Konstantine T; Kotoula, Vasiliki; Fountzilas, George; Rimm, David L Article Journal of the National Cancer Institute (2015)
Objective measurement and clinical significance of TILs in non-small cell lung cancer. Schalper, Kurt A; Brown, Jason; Carvajal-Hausdorf, Daniel; McLaughlin, Joseph; Velcheti, Vamsidhar; Syrigos, Konstantinos N; Herbst, Roy S; Rimm, David L Article Journal of the National Cancer Institute (2015)
Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic. Carvajal-Hausdorf, Daniel E; Schalper, Kurt A; Neumeister, Veronique M; Rimm, David L Article Laboratory investigation; a journal of technical methods and pathology (2015)
In situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas. Schalper, Kurt A; Velcheti, Vamsidhar; Carvajal, Daniel; Wimberly, Hallie; Brown, Jason; Pusztai, Lajos; Rimm, David L Article Clinical cancer research => an official journal of the American Association for Cancer Research (2014)
Possible role of hemichannels in cancer. Schalper, Kurt A; Carvajal-Hausdorf, Daniel; Oyarzo, Mauricio P Article Frontiers in physiology (2014)
Programmed death ligand-1 expression in non-small cell lung cancer. Velcheti, Vamsidhar; Schalper, Kurt A; Carvajal, Daniel E; Anagnostou, Valsamo K; Syrigos, Konstantinos N; Sznol, Mario; Herbst, Roy S; Gettinger, Scott N; Chen, Lieping; Rimm, David L Article Laboratory investigation; a journal of technical methods and pathology (2014)
[HER2 gene amplification and overexpression in advanced gastric cancer]. Roa, Iván; Slater, Jeannie; Carvajal, Daniel; Schalper, Kurt; de Toro, Gonzalo; Ares, Raúl; Game, Anakaren; León, Jorge; de Aretxabala, Xabier Article Revista medica de Chile (2013)
Breathing type and body position effects on sternocleidomastoid and suprahyoid EMG activity. de Mayo, T; Miralles, R; Barrero, D; Bulboa, A; Carvajal, D; Valenzuela, S; Ormeño, G Article Journal of oral rehabilitation (2005)
Evaluation of the impact of the COVID-19 pandemic in the diagnosis and treatment of breast cancer patients treated at Clínica Alemana de Santiago Barriga Sch, Carolina; Camacho N, Jamile; Román L, Eugenio; Retamal R, Tatiana; Cádiz V, Fernando; Gallegos A, Marcela; Carvajal H, Daniel Article SCIELO REVISTA CHILENA DE CIRUGIA

Daniel Carvajal

Patólogo Staff

Laboratorio Clínico, Banco de Sangre y Anatomía Patológica

Clínica Alemana - Facultad de Medicina Universidad del Desarrollo

Santiago, Chile

Franz Villarroel

Jefe Laboratorio - PI

Departamento de Investigación del Cáncer

Fundación Arturo López Pérez

Santiago, Chile

Daniel Eduardo Carvajal Hausdorf

Líneas de Investigación

Educación

Médico-Cirujano, UNIVERSIDAD DE CHILE. Chile, 2008

Médico Especialista en Anatomía Patológica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012

Experiencia Académica

Postdoctoral Associate Full Time

Profesor Investigador Asistente Adjunto Other

Formación de Capital Humano

Article (25)

Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)

Immune Checkpoint Inhibitor-Associated Pericarditis

Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry

An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients

Association of B7-H4, PD-L1, and tumor infiltrating lymphocytes with outcomes in breast cancer

Laparoscopic management of incidental gallbladder cancer

Macrodissection prior to closed system RT-qPCR is not necessary for estrogen receptor and HER2 concordance with IHC/FISH in breast cancer

Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer.

Effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes and PD-L1 expression in breast cancer and its clinical significance

High concordance of a closed-system, RT-qPCR breast cancer assay for HER2 mRNA, compared to clinically determined immunohistochemistry, fluorescence in situ hybridization, and quantitative immunofluorescence

Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer

Objective, domain-specific HER2 measurement in uterine and ovarian serous carcinomas and its clinical significance.

Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer.

Automated measurement of estrogen receptor in breast cancer=> a comparison of fluorescent and chromogenic methods of measurement.

EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma.

Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer.

Measurement of Domain-Specific HER2 (ERBB2) Expression May Classify Benefit From Trastuzumab in Breast Cancer.

Objective measurement and clinical significance of TILs in non-small cell lung cancer.

Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic.

In situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas.

Possible role of hemichannels in cancer.

Programmed death ligand-1 expression in non-small cell lung cancer.

[HER2 gene amplification and overexpression in advanced gastric cancer].

Breathing type and body position effects on sternocleidomastoid and suprahyoid EMG activity.

Evaluation of the impact of the COVID-19 pandemic in the diagnosis and treatment of breast cancer patients treated at Clínica Alemana de Santiago

Daniel Carvajal

Franz Villarroel