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Matthias Piesche

Assistant Professor

Universidad Católica del Maule

Talca, Chile

1. Cancer Immunotherapy - vaccines - macrophages 2. Cancer Biomarker - exosomes

Cancer Immunotherapy, University of Goettingen. Alemania, 2006

Postdoc Full Time

DANA-FARBER CANCER INSTITUTE

Estados Unidos

2007 - 2013
Senior Researcher Full Time

UNIVERSITY OF AARHUS

Dinamarca

2015 - 2017

Postdoc Full Time

Dana-Farber Cancer Institute

Estados Unidos

2007 - 2013
Senior Researcher Full Time

Aarhus University

Dinamarca

2015 - 2017
Instructor Full Time

Universidad Católica del Maule

Chile

2017 - 2019
Assistant Professor Full Time

Universidad Católica del Maule

Talca, Chile

2019 - At present


The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer Piesche, Matthias; Roos, Jessica; Kuehn, Benjamin; Fettel, Jasmin; Hellmuth, Nadine; Brat, Camilla; Maucher, Isabelle V.; Awad, Omar; Matrone, Carmela; Comerma Steffensen, Simon Gabriel; Manolikakes, Georg; Heinicke, Ulrike; Zacharowski, Kai D.; Steinhilber, Dieter; Maier, Thorsten J. Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy Roos, J; Peters, M; Maucher, IV; Kuhn, B; Fettel, J; Hellmuth, N; Brat, C; Sommer, B; Urbschat, A; Piesche, M; Vogel, A; Proschak, E; Blocher, R; Buscato, E; Hafner, AK; Matrone, C; Werz, O; Heidler, J; Wittig, I; Angioni, C; Geisslinger, G; Parnham, MJ; Zacharowski, K; Steinhilber, D; Maier, TJ Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2018)
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase=> A Possible Key to Future Antileukotriene Therapy. Roos, Jessica; Peters, Marcus; Maucher, Isabelle V; Kühn, Benjamin; Fettel, Jasmin; Hellmuth, Nadine; Brat, Camilla; Sommer, Benita; Urbschat, Anja; Piesche, Matthias; Vogel, Anja; Proschak, Ewgenij; Blöcher, René; Buscató, Estella; Häfner, Ann-Kathrin; Matrone, Carmela; Werz, Oliver; Heidler, Juliana; Wittig, Ilka; Angioni, Carlo; Geisslinger, Gerd; Parnham, Michael J; Zacharowski, Kai; Steinhilber, Dieter; Maier, Thorsten J Article Antioxidants & redox signaling (2018)
Ion Channel Function During Oocyte Maturation and Fertilization. Carvacho, Ingrid; Piesche, Matthias; Maier, Thorsten J; Machaca, Khaled Article Frontiers in cell and developmental biology (2018)
Combined Anti-VEGF and Anti-CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes. Wu, Xinqi; Li, Jingjing; Connolly, Erin M; Liao, Xiaoyun; Ouyang, Jing; Giobbie-Hurder, Anita; Lawrence, Donald; McDermott, David; Murphy, George; Zhou, Jun; Piesche, Matthias; Dranoff, Glenn; Rodig, Scott; Shipp, Margaret; Hodi, F Stephen Article Cancer immunology research (2017)
Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418. Maucher, Isabelle V; Rühl, Michael; Kretschmer, Simon B M; Hofmann, Bettina; Kühn, Benjamin; Fettel, Jasmin; Vogel, Anja; Flügel, Karsten T; Manolikakes, Georg; Hellmuth, Nadine; Häfner, Ann-Kathrin; Golghalyani, Vahid; Ball, Ann-Katrin; Piesche, Matthias; Matrone, Carmela; Geisslinger, Gerd; Parnham, Michael J; Karas, Michael; Steinhilber, Dieter; Roos, Jessica; Maier, Thorsten J Article Biochemical pharmacology (2017)
Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade. Zhou, Jun; Mahoney, Kathleen M; Giobbie-Hurder, Anita; Zhao, Fengmin; Lee, Sandra; Liao, Xiaoyun; Rodig, Scott; Li, Jingjing; Wu, Xinqi; Butterfield, Lisa H; Piesche, Matthias; Manos, Michael P; Eastman, Lauren M; Dranoff, Glenn; Freeman, Gordon J; Hodi, F Stephen Article Cancer immunology research (2017)
Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT Ho, VT; Kim, HT; Bavli, N; Mihm, M; Pozdnyakova, O; Piesche, M; Daley, H; Reynolds, C; Souders, NC; Cutler, C; Koreth, J; Alyea, EP; Antin, JH; Ritz, J; Dranoff, G; Soiffer, RJ Article ISI BLOOD ADVANCES (2017)
Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT. Ho, Vincent T; Kim, Haesook T; Bavli, Natalie; Mihm, Martin; Pozdnyakova, Olga; Piesche, Matthias; Daley, Heather; Reynolds, Carol; Souders, Nicholas C; Cutler, Corey; Koreth, John; Alyea, Edwin P; Antin, Joseph H; Ritz, Jerome; Dranoff, Glenn; Soiffer, Robert J Article Blood advances (2017)
Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors=> A basis for novel drugs targeting cancer cells? Roos, Jessica; Grösch, Sabine; Werz, Oliver; Schröder, Peter; Ziegler, Slava; Fulda, Simone; Paulus, Patrick; Urbschat, Anja; Kühn, Benjamin; Maucher, Isabelle; Fettel, Jasmin; Vorup-Jensen, Thomas; Piesche, Matthias; Matrone, Carmela; Steinhilber, Dieter; Parnham, Michael J; Maier, Thorsten J Article Pharmacology & therapeutics (2016)
Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma. Curry, William T; Gorrepati, Ramana; Piesche, Matthias; Sasada, Tetsuro; Agarwalla, Pankaj; Jones, Pamela S; Gerstner, Elizabeth R; Golby, Alexandra J; Batchelor, Tracy T; Wen, Patrick Y; Mihm, Martin C; Dranoff, Glenn Article Clinical cancer research => an official journal of the American Association for Cancer Research (2016)
Angiogenic cytokines are antibody targets during graft-versus-leukemia reactions. Piesche, Matthias; Ho, Vincent T; Kim, Haesook; Nakazaki, Yukoh; Nehil, Michael; Yaghi, Nasser K; Kolodin, Dmitriy; Weiser, Jeremy; Altevogt, Peter; Kiefel, Helena; Alyea, Edwin P; Antin, Joseph H; Cutler, Corey; Koreth, John; Canning, Christine; Ritz, Jerome; Soiffer, Robert J; Dranoff, Glenn Article Clinical cancer research => an official journal of the American Association for Cancer Research (2015)
Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3. Piesche, Matthias; Hildebrandt, York; Chapuy, Björn; Wulf, Gerald G; Trümper, Lorenz; Schroers, Roland Article Vaccine (2009)
Identification of a promiscuous HLA DR-restricted T-cell epitope derived from the inhibitor of apoptosis protein survivin. Piesche, Matthias; Hildebrandt, York; Zettl, Florian; Chapuy, Björn; Schmitz, Marc; Wulf, Gerald; Trümper, Lorenz; Schroers, Roland Article Human immunology (2007)
Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. Wolff, Sonja; Stöter, Martin; Giamas, Georgios; Piesche, Matthias; Henne-Bruns, Doris; Banting, George; Knippschild, Uwe Article FEBS letters (2006)
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. Prinz, Marco; Garbe, Folker; Schmidt, Hauke; Mildner, Alexander; Gutcher, Ilona; Wolter, Karina; Piesche, Matthias; Schroers, Roland; Weiss, Elisabeth; Kirschning, Carsten J; Rochford, Christian D P; Brück, Wolfgang; Becher, Burkhard Article The Journal of clinical investigation (2006)
Gene transfer into human T lymphocytes and natural killer cells by Ad5/F35 chimeric adenoviral vectors. Schroers, Roland; Hildebrandt, York; Hasenkamp, Justin; Glass, Bertram; Lieber, André; Wulf, Gerald; Piesche, Matthias Article Experimental hematology (2004)


Implementación de una unidad de microscopía confocal espectral para fortalecer la investigación en ciencias básicas, biotecnología y biomedicina en la región del Maule Echeverría-Vega, Alex; Piesche, M Proyecto (2021)
Dirigido al punto de control inmunosupresor fosfatidilserina para que la inmunoterapia contra el cáncer genere una potente inmunidad antitumoral Tamara Piña Proyecto Proyectos de Investigación con Financiamiento Interno 2020, línea de "proyectos de apoyo para estudiantes de pregrado SAPERE AUDE - atrévete a aprender" (2020)
Targeting the immunosuppressive checkpoint phosphatidylserine for cancer immunotherapy generates potent anti-tumor immunity PMI en Oncología (MECESUP UCM1301) Proyecto 2017-2017 Investigador(a)


Ion channel function during oocyte maturation and fertilization Carvacho I.; Piesche M.; Maier T.J.; Machaca K. Review ISI SCOPUS (2018)

Matthias Piesche

Assistant Professor

Medicina

Universidad Católica del Maule

Talca, Chile

Ingrid Carvacho

Assistant Professor

Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

Matthias Piesche

Líneas de Investigación

Educación

Cancer Immunotherapy, University of Goettingen. Alemania, 2006

Experiencia Académica

Postdoc Full Time

Senior Researcher Full Time

Experiencia Profesional

Postdoc Full Time

Senior Researcher Full Time

Instructor Full Time

Assistant Professor Full Time

Article (17)

The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase=> A Possible Key to Future Antileukotriene Therapy.

Ion Channel Function During Oocyte Maturation and Fertilization.

Combined Anti-VEGF and Anti-CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes.

Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.

Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade.

Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT

Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT.

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors=> A basis for novel drugs targeting cancer cells?

Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma.

Angiogenic cytokines are antibody targets during graft-versus-leukemia reactions.

Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3.

Identification of a promiscuous HLA DR-restricted T-cell epitope derived from the inhibitor of apoptosis protein survivin.

Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin.

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis.

Gene transfer into human T lymphocytes and natural killer cells by Ad5/F35 chimeric adenoviral vectors.

Proyecto (3)

Implementación de una unidad de microscopía confocal espectral para fortalecer la investigación en ciencias básicas, biotecnología y biomedicina en la región del Maule

Dirigido al punto de control inmunosupresor fosfatidilserina para que la inmunoterapia contra el cáncer genere una potente inmunidad antitumoral

Targeting the immunosuppressive checkpoint phosphatidylserine for cancer immunotherapy generates potent anti-tumor immunity

Review (1)

Ion channel function during oocyte maturation and fertilization

Matthias Piesche

Ingrid Carvacho