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Brian Alexander Effer Roldán

Postdoctorado

Universidad de La Frontera

Temuco, Chile

Producción de anticuerpos monoclonales de uso biotecnológico Bibliotecas génicas Fago display Ingeniería genética Bioquímica de proteínas Expresión y edición de proteínas recombinantes

Biología Celular y Molecular Aplicada, UNIVERSIDAD DE LA FRONTERA. Chile, 2019
Tecnología Bioquímica Farmacéutica, UNIVERSIDADE DE SAO PAULO. Brasil, 2019

Docente de Biotecnología Aplicada Part Time

UNIVERSIDAD DE LA FRONTERA

Facultad de Ingeniería y Ciencias

Temuco, Chile

2020 - At present
Docente de Biomedicina y Diagnostico Molecular Part Time

UNIVERSIDAD DE LA FRONTERA

Facultad de Ciencias Agropecuarias y del Medio Ambiente

Temuco, Chile

2020 - At present

Investigador Full Time

Proyecto FONDEF D10I1064

TEMUCO, Chile

2012 - 2014
Investigador Full Time

Proyecto FONDECYT 1120705

Temuco, Chile

2012 - 2014
Tesista Full Time

Proyecto FAPESP 3/08617-7

Sao Paulo, Brasil

2015 - 2019
Investigador Principal Full Time

Proyecto FONDECYT de postdoctorado 3210142

Temuco, Chile

2021 - At present


Construction of a Human Immune Library from Gallbladder Cancer Patients for the Single-Chain Fragment Variable (<i>scFv</i>) Antibody Selection against Claudin 18.2 via Phage Display Effer, Brian; Ulloa, Daniel; Dappolonnio, Camila; Munoz, Francisca; Iturrieta-Gonzalez, Isabel; Cotes, Loraine; Rojas, Claudio; Leal, Pamela Article ISI ANTIBODIES (2024)
Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line Costa, Iris Munhoz; Effer, Brian; Costa-Silva, Tales Alexandre; Chen, Chen; Ciccone, Michael F.; Pessoa, Adalberto; dos Santos, Camila O.; Monteiro, Gisele Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Current state of molecular and metabolic strategies for the improvement of L-asparaginase expression in heterologous systems Lefin, N.; Miranda, J.; Beltrán, J.; Effer, B.; Pessoa, A.; Farias, J.; Zamorano, M. Article FRONTIERS IN PHARMACOLOGY (2023)
Downstream process and evaluation of the concomitant impact of a recombinant glycosylated L-asparaginase on leukemic cancer cells and the bone marrow tumor microenvironment Kleingesinds, Eduardo Krebs; Parizotto, Leticia de Almeida; de Almeida Parizotto, Letícia; Effer, Brian; Monteiro, Gisele; Long, Paul F.; Arroyo-Berdugo, Yoana; Behrends, Volker; Esposito, Maria Teresa; Calle, Yolanda; Pessoa, Adalberto Article ISI SCOPUS PROCESS BIOCHEMISTRY (2023)
Therapeutic Targets of Monoclonal Antibodies Used in the Treatment of Cancer: Current and Emerging Effer, Brian; Perez, Isabela; Ulloa, Daniel; Mayer, Carolyn; Munoz, Francisca; Bustos, Diego; Rojas, Claudio; Manterola, Carlos; Vergara-Gomez, Luis; Dappolonnio, Camila; WEBER-RASCHEYA, HELGA LORENA; Leal, Pamela Article ISI SCOPUS Biomedicines (2023)
A low-cost system for the study of proteins used in salmonid diets, use of proteolysis to determine the quality Jorge Parodi; Hector Herrera; Rodrigo Sanchez; Brian Effer Article LWT-FOOD SCIENCE AND TECHNOLOGY (2022)
Increased glycosylated L-asparaginase production through selection of Pichia pastoris plataform and oxygen-methanol control in fed-batches Parizotto, L.; Kleingesinds, E.; Da Rosa, L.; Effer, B.; Lima, G.; Herkenhoff, M.; Li, Z.; Rinas, U.; Monterio, G.; Pessoa, A.; Tonso, A. Article BIOCHEMICAL ENGINEERING JOURNAL (2021)
Increased glycosylated Lasparaginase production through selection of pichia pastoris plataform and oxygenmethanol control in fed-batches Parizotto, L.; Kleingesinds, Eduardo Krebs; da Rosa, L; Effer, Brian; Lima, G.; Herkenhoff, M.; Li, Z.; Monteiro, G.; Pessoa, A.; Tonso, Aldo Article BIOCHEMICAL ENGINEERING JOURNAL (2021)
Structure of the Mycobacterium tuberculosis cPknF and conformational changes induced in Forkhead-Associated regulatory domains Cabarca, Sindy; Frazão de Souza, M; Albert de Oliveira, A; Vignoli Muniz, G.S.; Lamy, M.T.; Vinicius dos Reis, C; Takarada, J; Effer, B; Souza, L.S.; Iriarte de la Torre, L; Cuñago, R; Pinto Oliveira, C.L.; Balan, A Article Current Research in Structural Biology (2021)
Glycosylation of Erwinase results in active protein less recognized by antibodies Effer, Brian; Kleingesinds, Eduardo Krebs; Lima, Guilherme Meira; Costa, Iris Munhoz; Sánchez-Moguel, Ignacio; Pessoa, Adalberto; Santiago, Verônica Feijoli; Palmisano, Giuseppe; Farías, Jorge G.; Monteiro, Gisele Article BIOCHEMICAL ENGINEERING JOURNAL (2020)
Glycosylation of L-asparaginase from E. coli through yeast expression and site-directed mutagenesis Lima G.M.; Effer B.; Biasoto H.P.; Feijoli V.; Pessoa, A.; Palmisano G.; Monteiro G. Article ISI SCOPUS (2020)
A structural in silico analysis of the immunogenicity of L-asparaginase from Escherichia coli and Erwinia carotovora BelÃ©n L.H.; Lissabet J.B.; de Oliveira Rangel-Yagui C.; Effer B.; Monteiro G.; Pessoa, A.; FarÃas AvendaÃ±o J.G. Article ISI SCOPUS BIOLOGICALS (2019)
L-Asparaginase from E. chrysanthemi expressed in glycoswitch: effect of His-Tag fusion on the extracellular expression Effer, Brian; Lima, Guilherme Meira; Cabarca, Sindy; Pessoa, Adalberto; Farias, Jorge G.; Monteiro, Gisele Article ISI SCOPUS PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY (2019)
Effect of seminal plasma on Atlantic salmon (Salmo salar) sperm vitrification Figueroa, E.; Merino, O.; Risopatrón J.; Isachenko V.; Sanchez R.; Effer B.; Isachenko E.; Farías J.G.; Valdebenito I. Article ISI SCOPUS THERIOGENOLOGY (2015)
Short-term cold storage of the semen of rainbow trout Oncorhynchus mykiss (Walbaum, 1792) incorporating DMSO in the sperm diluent. Effects on motility and fertilizing capacity Ubilla A.; Fornari, D; Figueroa, E.; Effer B.; Valdebenito I. Article ISI SCOPUS Aquaculture Research (2015)
Morphometric of blastomeres in Salmo salar Effer, BR; Sanchez, RR; Ubilla, AM; Figueroa, EV; Valdebenito, II Article ISI SCOPUS ZYGOTE (2014)
Gamete quality in fish: Evaluation parameters and determining factors Valdebenito I.I.; Gallegos P.C.; Effer B.R. Article ISI SCOPUS Zygote (2013)
Sperm biology of Merluccius australis: Sperm structure, semen characteristics and effects of pH, temperature and osmolality on sperm motility Effer B.; Figueroa, E.; Augsburger A.; Valdebenito I. Article ISI SCOPUS Aquaculture (2013)
Study of the first blastomeres in Coho salmon (Oncorhynchus kisutch) Roldan, BE; Rueda, RS; Madrid, AU; Villalobos, EF; Isler, IV Article ISI SCOPUS Zygote (2013)
Morphometric characterization of the first blastomeres of rainbow trout (Oncorhynchus mykiss) Valdebenitol I.I.; Sanchez R.R.; Effer B.R.; Ubilla A.M. Article ISI SCOPUS Zygote (2012)


A versatile platform to produce monoclonal antibodies (mAbs) against biomarkers overexpressed in the most lethal cancers: Towards the national sustainable production of proteins with biopharmaceutical and biotechnological purpose Brian Effer Proyecto (2024)
Librerías génicas: Una plataforma versátil para obtener anticuerpos contra la tuberculosis en humanos. : ISABEL ANTONIETA ITURRIETA GONZALEZ; Effer, Brian Proyecto (2024)
Setting up de una plataforma de Phage – ribosome display para la obtención de anticuerpos monoclonales para cáncer de vesícula biliar: Nueva fuente de aplicación diagnóstica y de terapia Brian Effer Proyecto (2021)
Produção de L-asparaginase extracelular=> da bioprospecção à engenharia de um biofármaco antileucêmico FAPESP (3/08617-7) Proyecto 2013-2019 Tesista
Optimización del manejo artificial de la reproducción de salmonidos utilizando la criobiología como herramienta biotecnológica FONDEF (D10I1064) Proyecto 2012-2014 Investigador(a)
Study of the physiological and genetic aspects related with gamete aging in salmonids. FONDECYT (1120705) Proyecto 2012-2014 Investigador(a)


From Synthesis to Characterization of Site-Selective PEGylated Proteins BelÃ©n L.H.; De Oliveira Rangel-Yagui C.; BeltrÃ¡n Lissabet J.F.; Effer B.; Lee-Estevez M.; Pessoa, A.; Castillo R.L.; FarÃas J.G. Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)