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Leonel Alexis Muñoz Sagredo

Profesor Adjunto

Universidad de Valparaíso

Viña del Mar, Chile

Liver premetastatic niche in pancreatic cancer mouse models. Zebrafish xenograft cancer models. Patient derived organoids. Cell plasticity in colorectal cancer. Alternative splicing quantification.

PhD in Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2014
General Adult Surgery, UNIVERSIDAD DE VALPARAISO. Chile, 2006
General practitioner, UNIVERSIDAD DE CHILE. Chile, 1999
Applied Biostatistics, UNIVERSIDAD DE CHILE. Chile, 2004

Profesor Adjunto Part Time

UNIVERSIDAD DE VALPARAISO

Medicine

Viña del Mar, Chile

2014 - At present
Postdoctoral Fellow Other

KARLSRUHE INSTITUTE OF TECHNOLOGY

Institute Of Toxicology and Genetics

Karlsruhe, Alemania

2015 - 2017
Postdoctoral position Full Time

KARLSRUHE INSTITUTE OF TECHNOLOGY

Institute of Biological and Chemical Systems

Karlsruhe, Chile

2017 - 2021

Médico general Full Time

Consultorio San Rafael de La Pintana

Santiago, Chile

1999 - 1999
Médico general de zona Full Time

Hospital de Chile Chico

Chile Chico, Chile

1999 - 2003
Cirujano general y de urgencia Full Time

Hospital Dr. Gustavo Fricke/ Servivio de Salud Viña del Mar-quillotra

Viña del Mar, Chile

2003 - 2007
Surgeon, emergency department Part Time

Hospital de Urgencia Asistencia Pública/ Servicio de Salud Metropolitano Central

Santiago, Chile

2008 - 2009
Surgeon, emergency department. Part Time

Hospital Dr. Gustavo Fricke/ Servicio de Salud Viña del mar Quillota

Viña del Mar, Chile

2010 - 2013
Surgeon, upper GI team. Part Time

Hospital Dr. Gustavo Fricke/ Servicio de Salud Viña del Mar Quillota

Viña del Mar, Chile

2014 - 2015
Profesor Auxiliar Part Time

Universidad de Valparaiso/Escuela de Medicina

Valparaiso/ Viña del Mar, Chile

2014 - At present
Cirujano Digestivo Part Time

Hospital Dr. Gustavo Fricke/ Servicio de Salud Viña del mar-quillotra

Viña Del Mar, Chile

2021 - At present

Adjudicación de Beca de Postdoctorado en el Extranjero Becas Chile, Convocatoria 2014. Proyecto titulado: Cancer Cell Reprogramming by Extracellular Signals en el Karlsruhe Institute Of Technology, Alemania.

Reconocimiento como mejor docente Ad-Honorem

UNIVERSIDAD DE VALPARAISO

Chile, 2006

Reconocimiento como Mejor Docente Ad Honorem por la promoción de Médicos-Cirujanos 2006, Universidad de Valparaíso. Otorgado en relación a docencia clínica como docente colaborador.


Ca<SUP>2+</SUP> signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder Cortes, Magdalena P.; Alonso, Catalina; Vinet, Raul; Valdivia-Cortes, Karla; Munoz-Sagredo, Leonel; Bahamondez-Canas, Tania F.; Cardenas, Ana Maria Article ISI BIOMEDICAL REPORTS (2024)
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs Rosso, Ilaria; Jones-Weinert, Corey; Rossiello, Francesca; Cabrini, Matteo; Brambillasca, Silvia; Munoz-Sagredo, Leonel; Lavagnino, Zeno; Martini, Emanuele; Tedone, Enzo; Garre, Massimiliano; Aguado, Julio; Parazzoli, Dario; Mione, Marina; Shay, Jerry W.; Mercurio, Ciro; di Fagagna, Fabrizio d'Adda Article ISI NATURE COMMUNICATIONS (2023)
Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer Xu, Tong; Verhagen, Mathijs; Joosten, Rosalie; Sun, Wenjie; Sacchetti, Andrea; Sagredo, Leonel Munoz; Orian-Rousseau, Veronique; Fodde, Riccardo Article ISI ELIFE (2022)
Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop Walter, Romina J.; Sonnentag, Steffen J.; Munoz-Sagredo, Leonel; Merkel, Melanie; Richert, Ludovic; Bunert, Felix; Heneka, Yvonne M.; Loustau, Thomas; Hodder, Michael; Ridgway, Rachel A.; Sansom, Owen J.; Mely, Yves; Rothbauer, Ulrich; Schmitt, Mark; Orian-Rousseau, Veronique Article ISI CELL DEATH & DISEASE (2022)
CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues Yu, Xiaobing; Munoz-Sagredo, Leonel; Streule, Karolin; Muschong, Patricia; Bayer, Elisabeth; Walter, Romina J.; Gutjahr, Julia C.; Greil, Richard; Conch, Miguel L.; Mueller-Tidow, Carsten; Hartmann, Tanja N.; Orian-Rousseau, Veronique Article ISI BLOOD (2021)
Plasticity in Colorectal Cancer: Why Cancer Cells Differentiate Walter, Romina Judith; Sonnentag, Steffen Joachim; Orian-Rousseau, Veronique; Munoz-Sagredo, Leonel Article ISI CANCERS (2021)
Breast Cancer-Derived Microparticles Reduce Cancer Cell Adhesion, an Effect Augmented by Chemotherapy Shechter, Dvir; Harel, Michal; Mukherjee, Abhishek; Sagredo, Leonel M.; Loven, David; Prinz, Elad; Avraham, Shimrit; Orian-Rousseau, Veronique; Geiger, Tamar; Shaked, Yuval; Wolfenson, Haguy Article ISI CELLS (2020)
Combinatorial Synthesis of a Lipidoid Library by Thiolactone Chemistry: In Vitro Screening and in Vivo Validation for siRNA Delivery Molla M.R.; Chakraborty S.; Munoz-Sagredo L.; Drechsler M.; Orian-Rousseau V.; Levkin P.A. Article SCOPUS Bioconjugate Chemistry (2020)
Fam83F induces p53 stabilisation and promotes its activity Salama M.; Benitez-Riquelme D.; Elabd S.; Munoz L.; Zhang P.; Glanemann M.; Mione M.C.; Goldin R.; Soussi T.; Davidson G.; Blattner C. Article ISI SCOPUS CELL DEATH AND DIFFERENTIATION (2019)
Gd-4(3+)[AlPCS4](3)(4-) Nanoagent Generating O-1(2) for Photodynamic Therapy Poss, Marieke; Zittel, Eva; Seidl, Carmen; Meschkov, Anna; Munoz, Leonel; Schepers, Ute; Feldmann, Claus Article ISI ADVANCED FUNCTIONAL MATERIALS (2018)
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression Anelli, V; Ordas, A; Kneitz, S; Sagredo, LM; Gourain, V; Schartl, M; Meijer, AH; Mione, M Article ISI FRONTIERS IN GENETICS (2018)
Prediction of chemotherapy response and metabolism for the tailoring of ovarian cancer treatment Loreto Bravo, Maria; Gonzalez, Pamela; Kato, Sumie; Ibanez, Carolina; Garrido, Marcelo; Branes, Jorge; Isabel Barriga, Maria; Bustamante, Eva; Barrena, Nicanor; Alonso, Catalina; Munoz, Leonel; Bravo, Erasmo; Arab, Clemente; Barra, Alejandro; Jimenez, Paula; Gayan, Patricio; Gonzalez, Fernando; Chavez, Ignacio; Aguilar, Alfredo; Pinto, Joseph; Cuello, Mauricio; Owen, Gareth; Cartagena, Jaime Article ISI CANCER RESEARCH (2015)
Células tronacales en el desarrollo y las perspectivas de reprogramación celular para regeneración Muñoz, Leonel; Concha, Miguel Luis Article SCIELO INTERNATIONAL JOURNAL OF MORPHOLOGY (2012)
Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients Tittarelli, A; González F.E.; Pereda, C; Mora, G; Munoz L.; Saffie C; Garcia, T.; Diaz, D.; Falcon, C; Hermoso, M; López, M N.; SALAZAR ONFRAY F Article ISI SCOPUS Cancer Immunology, Immunotherapy (2012)
Prolonged Survival of Dendritic Cell-Vaccinated Melanoma Patients Correlates With Tumor-Specific Delayed Type IV Hypersensitivity Response and Reduction of Tumor Growth Factor beta-Expressing T Cells López MN; Pereda, C; Segal G; Munoz L.; Aguilera R.; Gonzalez, FE; Escobar A.; Ginesta, A; Reyes, D; González R.; Mendoza-Naranjo, A; Larrondo M.; Compan A.; Ferrada C.; SALAZAR ONFRAY F Article ISI JOURNAL OF CLINICAL ONCOLOGY (2009)


MiRNAs in Malignant Melanoma Marina Mione; Janika Liebig; Leonel Munoz; Anja Bosserhof BookSection (2017)
Politraumatizado Muñoz Sagredo, Leonel; Caimi, LM; Caimi, Leonardo; Caimi, Paolo BookSection (2013)


The impact of CD44 on the metastatic niche of pancreatic cancer Munoz-Sagredo, Leonel; Mehner, Lisa-Marie; Orian-Rousseau, Veronique ConferencePoster (2019)
Whole organism in vivo real-time high resolution follow-up of human colon cancer xenograft models in zebrafish, reveals that engraftment to specific environments is related to type of interaction between cancer cells Munoz-Sagredo, Leonel; Takamiya, Masanari; Orian-Rousseau, Veronique; Mione, Marina; Sleeman, Jonathan ConferencePoster (2017)


The contribution of platelets to intravascular arrest, extravasation, and outgrowth of disseminated tumor cells Foss A.; MuÃ±oz-Sagredo L.; Sleeman J.; Thiele W. Review ISI SCOPUS CLINICAL & EXPERIMENTAL METASTASIS (2020)