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Soledad Bárez López

Investigados Principal

Consejo Superior de Investigaciones Científicas

Madrid, España

My research line has focused on the field of Neuroedocrinology. Most of my research has focused on elucidating thyroid hormone action in brain and on investigating the synthesis and release mechanisms of oxitocyn and vaspressin in the brain.

Neuroendocrinología, UNIVERSIDAD AUTONOMA DE MADRID. España, 2017
Neurociencia, UNIVERSITY OF SUSSEX. Reino Unido, 2011
Biología, UNIVERSIDAD AUTONOMA DE MADRID. España, 2010

Investigador Principal Full Time

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

España

2022 - At present
Postdoctoral Researcher Full Time

UNIVERSITY OF BRISTOL

Reino Unido

2019 - 2022
Postdoctoral Researcher Full Time

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

España

2017 - 2018

Investigador Principal Full Time

Consejo Superior de Investigaciones Científicas

España

2022 - At present
Postdoctoral Researcher Full Time

University of Bristol

Reino Unido

2019 - 2022
Postdoctoral Researcher Full Time

Consejo Superior de Investigaciones Científicas

España

2017 - 2018


Male rat hypothalamic extraretinal photoreceptor Opsin3 is sensitive to osmotic stimuli and light Barez-Lopez, Soledad; Bishop, Paul; Searby, Daniel; Murphy, David; Greenwood, Michael P. Article ISI JOURNAL OF NEUROENDOCRINOLOGY (2024)
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction Neves, Joao Sergio; Leite, Ana Rita; Conceicao, Gloria; Goncalves, Alexandre; Borges-Canha, Marta; Vale, Catarina; Von-Hafe, Madalena; Martins, Diana; Miranda-Silva, Daniela; Leite, Sara; Rocha-Oliveira, Estela; Sousa-Mendes, Claudia; Chaves, Joana; Lourenco, Ines Mariana; Grijota-Martinez, Carmen; Barez-Lopez, Soledad; Miranda, Isabel M. M.; Almeida-Coelho, Joao; Vasques-Novoa, Francisco; Carvalho, Davide; Lourenco, Andre; Falcao-Pires, Ines; Leite-Moreira, Adelino Article ISI THYROID (2023)
Imaging the hypothalamo-neurohypophysial system Barez-Lopez, S.; Scanlon, L.; Murphy, D.; Greenwood, M. P. Article ISI NEUROENDOCRINOLOGY (2023)
Isoflurane rapidly modifies synaptic and cytoskeletal phosphoproteomes of the supraoptic nucleus of the hypothalamus and the cortex Barez-Lopez, Soledad; Gadd, George J.; Pauza, Audrys G.; Murphy, David; Greenwood, Michael P. Article ISI NEUROENDOCRINOLOGY (2023)
Maternal Administration of the CNS-Selective Sobetirome Prodrug Sob-AM2 Exerts Thyromimetic Effects in Murine MCT8-Deficient Fetuses Valcarcel-Hernandez, Victor; Guillen-Yunta, Marina; Scanlan, Thomas S.; Barez-Lopez, Soledad; Guadano-Ferraz, Ana Article ISI THYROID (2023)
Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release Greenwood, Michael P.; Greenwood, Mingkwan; Barez-Lopez, Soledad; Hawkins, Joe W.; Short, Katherine; Tatovic, Danijela; Murphy, David Article ISI MOLECULAR METABOLISM (2023)
A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations Valcarcel-Hernandez, Victor; Guillen-Yunta, Marina; Bueno-Arribas, Miranda; Montero-Pedrazuela, Ana; Grijota-Martinez, Carmen; Markossian, Suzy; Garcia-Aldea, Angel; Flamant, Frederic; Barez-Lopez, Soledad; Guadano-Ferraz, Ana Article ISI NEUROBIOLOGY OF DISEASE (2022)
Deficient thyroid hormone transport to the brain leads to impairments in axonal caliber and oligodendroglial development Valcarcel-Hernandez, Victor; Lopez-Espindola, Daniela; Guillen-Yunta, Marina; Garcia-Aldea, Angel; de Toledo Soler, Ines Lopez; Barez-Lopez, Soledad; Guadano-Ferraz, Ana Article ISI NEUROBIOLOGY OF DISEASE (2022)
Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2 Barez-Lopez, Soledad; Konopacka, Agnieszka; Cross, Stephen J.; Greenwood, Mingkwan; Skarveli, Marina; Murphy, David; Greenwood, Michael P. Article ISI NEUROENDOCRINOLOGY (2022)
Intranasal delivery of Thyroid hormones in MCT8 deficiency Grijota-Martinez, Carmen; Barez-Lopez, Soledad; Auso, Eva; Refetoff, Samuel; Frey, William H., II; Guadano-Ferraz, Ana Article ISI PLOS ONE (2020)
Adult Mice Lacking Mct8 and Dio2 Proteins Present Alterations in Peripheral Thyroid Hormone Levels and Severe Brain and Motor Skill Impairments Barez-Lopez, Soledad; Grijota-Martinez, Carmen; Auso, Eva; Fernandez-de Frutos, Mario; Montero-Pedrazuela, Ana; Guadano-Ferraz, Ana Article ISI THYROID (2019)
Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8 Barez-Lopez, Soledad; Grijota-Martinez, Carmen; Liao, Xiao-Hui; Refetoff, Samuel; Guadano-Ferraz, Ana Article ISI PLOS ONE (2019)
Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain Barez-Lopez, Soledad; Hartley, Meredith D.; Grijota-Martinez, Carmen; Scanlan, Thomas S.; Guadano-Ferraz, Ana Article ISI THYROID (2018)
Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development Barez-Lopez, Soledad; Jesus Obregon, Maria; Bernal, Juan; Guadano-Ferraz, Ana Article ISI CEREBRAL CORTEX (2018)
Increased anxiety and fear memory in adult mice lacking type 2 deiodinase Barez-Lopez, Soledad; Montero-Pedrazuela, Ana; Bosch-Garcia, Daniel; Venero, Cesar; Guadano-Ferraz, Ana Article ISI PSYCHONEUROENDOCRINOLOGY (2017)
Adeno Associated Virus 9-Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice Iwayama, Hideyuki; Liao, Xiao-Hui; Braun, Lyndsey; Barez-Lopez, Soledad; Kaspar, Brian; Weiss, Roy E.; Dumitrescu, Alexandra M.; Guadano-Ferraz, Ana; Refetoff, Samuel Article ISI THYROID (2016)
Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution Barez-Lopez, Soledad; Jesus Obregon, Maria; Martinez-de-Mena, Raquel; Bernal, Juan; Guadano-Ferraz, Ana; Morte, Beatriz Article ISI THYROID (2016)
Abnormal Motor Phenotype at Adult Stages in Mice Lacking Type 2 Deiodinase Barez-Lopez, Soledad; Bosch-Garcia, Daniel; Gomez-Andres, David; Pulido-Valdeolivas, Irene; Montero-Pedrazuela, Ana; Obregon, Maria Jesus; Guadano-Ferraz, Ana Article ISI PLOS ONE (2014)


MCT8 Deficiency: The Road to Therapies for a Rare Disease Grijota-Martinez, Carmen; Barez-Lopez, Soledad; Gomez-Andres, David; Guadano-Ferraz, Ana Review ISI FRONTIERS IN NEUROSCIENCE (2020)
Thyroid Hormone Availability and Action during Brain Development in Rodents Barez-Lopez, Soledad; Guadano-Ferraz, Ana Review ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Soledad Bárez

Investigados Principal

Consejo Superior de Investigaciones Científicas

Madrid, España

Daniela López

Profesora Adjunta

UNIVERSIDAD DE VALPARAISO

Viña de Mar, Chile

Soledad Bárez López

Líneas de Investigación

Educación

Neuroendocrinología, UNIVERSIDAD AUTONOMA DE MADRID. España, 2017

Neurociencia, UNIVERSITY OF SUSSEX. Reino Unido, 2011

Biología, UNIVERSIDAD AUTONOMA DE MADRID. España, 2010

Experiencia Académica

Investigador Principal Full Time

Postdoctoral Researcher Full Time

Postdoctoral Researcher Full Time

Experiencia Profesional

Investigador Principal Full Time

Postdoctoral Researcher Full Time

Postdoctoral Researcher Full Time

Article (18)

Male rat hypothalamic extraretinal photoreceptor Opsin3 is sensitive to osmotic stimuli and light

Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction

Imaging the hypothalamo-neurohypophysial system

Isoflurane rapidly modifies synaptic and cytoskeletal phosphoproteomes of the supraoptic nucleus of the hypothalamus and the cortex

Maternal Administration of the CNS-Selective Sobetirome Prodrug Sob-AM2 Exerts Thyromimetic Effects in Murine MCT8-Deficient Fetuses

Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release

A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations

Deficient thyroid hormone transport to the brain leads to impairments in axonal caliber and oligodendroglial development

Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2

Intranasal delivery of Thyroid hormones in MCT8 deficiency

Adult Mice Lacking Mct8 and Dio2 Proteins Present Alterations in Peripheral Thyroid Hormone Levels and Severe Brain and Motor Skill Impairments

Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8

Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain

Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development

Increased anxiety and fear memory in adult mice lacking type 2 deiodinase

Adeno Associated Virus 9-Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice

Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution

Abnormal Motor Phenotype at Adult Stages in Mice Lacking Type 2 Deiodinase

Review (2)

MCT8 Deficiency: The Road to Therapies for a Rare Disease

Thyroid Hormone Availability and Action during Brain Development in Rodents

Soledad Bárez

Daniela López