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Silvana Abisag Valdebenito Silva

Assistant Professor

The University of Texas Medical Branch

Galveston, Estados Unidos

My research focuses on the study of cell-to-cell communication, in particular, the role of tunneling nanotubes in viral infections of the brain

Quimica, UNIVERSIDAD DE CHILE. Chile, 2016
Quimico, UNIVERSIDAD DE CHILE. Chile, 2010

Assistant Professor Full Time

The University Of Texas Medical Branch

Galveston, Estados Unidos

2023 - At present


The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency Sperber, Hannah S.; Raymond, Kyle A.; Bouzidi, Mohamed S.; Ma, Tongcui; Valdebenito, Silvana; Eugenin, Eliseo A.; Roan, Nadia R.; Deeks, Steven G.; Winning, Sandra; Fandrey, Joachim; Schwarzer, Roland; Pillai, Satish K. Article ISI CELL REPORTS (2023)
Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain Donoso, Maribel; D'Amico, Daniela; Valdebenito, Silvana; Hernandez, Cristian A.; Prideaux, Brendan; Eugenin, Eliseo A. Article ISI CELLS (2022)
Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19 Zhu, Aiwei; Real, Fernando; Capron, Claude; Rosenberg, Arielle R.; Silvin, Aymeric; Dunsmore, Garett; Zhu, Jaja; Cottoignies-Callamarte, Andrea; Masse, Jean-Marc; Moine, Pierre; Bessis, Simon; Godement, Mathieu; Geri, Guillaume; Chiche, Jean-Daniel; Valdebenito, Silvana; Belouzard, Sandrine; Dubuisson, Jean; de la Grandmaison, Geoffroy Lorin; Chevret, Sylvie; Ginhoux, Florent; Eugenin, Eliseo A.; Annane, Djillali; Borde, Elisabeth Cramer; Bomsel, Morgane Article ISI CELLULAR AND MOLECULAR LIFE SCIENCES (2022)
Astrocytes are HIV reservoirs in the brain: A cell type with poor HIV infectivity and replication but efficient cell-to-cell viral transfer Valdebenito, Silvana; Castellano, Paul; Ajasin, David; Eugenin, Eliseo A. Article ISI JOURNAL OF NEUROCHEMISTRY (2021)
COVID-19 Lung Pathogenesis in SARS-CoV-2 Autopsy Cases Valdebenito, Silvana; Bessis, Simon; Annane, Djillali; de la Grandmaison, Geoffroy Lorin; Cramer-Borde, Elisabeth; Prideaux, Brendan; Eugenin, Eliseo A.; Bomsel, Morgane Article ISI FRONTIERS IN IMMUNOLOGY (2021)
Human immunodeficiency virus-1/simian immunodeficiency virus infection induces opening of pannexin-1 channels resulting in neuronal synaptic compromise: A novel therapeutic opportunity to prevent NeuroHIV Gorska, Anna Maria; Donoso, Maribel; Valdebenito, Silvana; Prideaux, Brendan; Queen, Suzanne; Scemes, Eliana; Clements, Janice; Eugenin, Eliseo Article ISI JOURNAL OF NEUROCHEMISTRY (2021)
Pannexin-1 channel opening is critical for COVID-19 pathogenesis Luu, Ross; Valdebenito, Silvana; Scemes, Eliana; Cibelli, Antonio; Spray, David C.; Rovegno, Maximiliano; Tichauer, Juan; Cottignies-Calamarte, Andrea; Rosenberg, Arielle; Capron, Calude; Belouzard, Sandrine; Dubuisson, Jean; Annane, Djillali; de la Grandmaison, Geoffroy Lorin; Cramer-Borde, Elisabeth; Bomsel, Morgane; Eugenin, Eliseo Article ISI ISCIENCE (2021)
Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions Valdebenito, Silvana; Malik, Shaily; Luu, Ross; Loudig, Olivier; Mitchell, Megan; Okafo, George; Bhat, Krishna; Prideaux, Brendan; Eugenin, Eliseo A. Article ISI SCIENTIFIC REPORTS (2021)
Circulating levels of ATP is a biomarker of HIV cognitive impairment Velasquez, Stephani; Prevedel, Lisa; Valdebenito, Silvana; Gorska, Anna Maria; Golovko, Mikhail; Khan, Nabab; Geiger, Jonathan; Eugenin, Eliseo A. Article ISI EBIOMEDICINE (2020)
Role of Tunneling Nanotube-like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread Okafo, George; Valdebenito, Silvana; Donoso, Maribel; Luu, Ross; Ajasin, David; Prideaux, Brendan; Gorantla, Santhi; Eugenin, Eliseo A. Article ISI JOURNAL OF IMMUNOLOGY (2020)
Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment Valdebenito, Silvana; Audia, Alessandra; Bhat, Krishna P. L.; Okafo, George; Eugenin, Eliseo A. Article ISI ISCIENCE (2020)
Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland Eugenin E.A.; Valdebenito S.; Gorska A.M.; MartÃnez A.D.; Bitran M.; SÃ¡ez J.C. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2019)
HIV infection and latency induce a unique metabolic signature in human macrophages Castellano, Paul; Prevedel, Lisa; Valdebenito, Silvana; Eugenin, Eliseo A. Article ISI SCIENTIFIC REPORTS (2019)
Intense White Molecular Fluorescence from Naphthoxazole-Quinoline Derivatives Zanocco R.P.; Valdebenito S.; Gidi Y.; Zapata-Torres G; Lemp E.; Nonell S.; Zanocco, A. L. Article ISI SCOPUS Photochemistry and Photobiology (2018)
The role of connexin and pannexin containing channels in the innate and acquired immune response Valdebenito, Silvana; Barreto, Andrea; Eugenin, Eliseo A. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)
Experimental and theoretical studies of the photophysics of 7-amino-3-phenyl-2H-benzo[b] [1,4]oxazin-2-one in homogeneous solvents and beta-cyclodextrin aqueous solutions Valdebenito S.; Zapata-Torres, G; Lemp E.; Zanocco, AL Article ISI AFINIDAD (2015)
Solvent and compartmentalization effects on the photophysics of 4-(benzothiazol-2-yl)-N,N-diphenylaniline Valdebenito S.; Zanocco, R; Gunther, G.; Lemp E.; Zanocco, AL Article ISI SCOPUS Afinidad (2011)


PHOTOCHEMICAL AND PHOTOPHYSICAL STUDY OF NEW FLUORECENT DYES. II=> SUBSTITUTED NAPHTHOXAZOLES FONDECYT (1080410) Proyecto 2008-2010 Tesista


HIV infection of astrocytes compromises inter-organelle interactions and inositol phosphate metabolism: A potential mechanism of bystander damage and viral reservoir survival Malik, Shaily; Valdebenito, Silvana; D'Amico, Daniela; Prideaux, Brendan; Eugenin, Eliseo A. Review ISI PROGRESS IN NEUROBIOLOGY (2021)
The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus D'Amico, Daniela; Valdebenito, Silvana; Eugenin, Eliseo A. Review ISI PURINERGIC SIGNALLING (2021)
Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools Valdebenito, Silvana; D'Amico, Daniela; Eugenin, Eliseo Review ISI CANCER REPORTS (2019)
The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis Valdebenito, Silvana; Lou, Emil; Baldoni, John; Okafo, George; Eugenin, Eliseo Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
The Crucial Role of Biofilms in <i>Cryptococcus neoformans</i> Survival within Macrophages and Colonization of the Central Nervous System Aslanyan, Lilit; Sanchez, David A.; Valdebenito, Silvana; Eugenin, Eliseo A.; Ramos, Raddy L.; Martinez, Luis R. Review ISI JOURNAL OF FUNGI (2017)

Silvana Valdebenito

Assistant Professor

Neurobiology

The University of Texas Medical Branch

Galveston, Estados Unidos

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

GERMAN GUNTHER

PROFESOR Titular

Química Orgánica y Físico Química

UNIVERSIDAD DE CHILE

Santiago, Chile

Silvana Abisag Valdebenito Silva

Líneas de Investigación

Educación

Quimica, UNIVERSIDAD DE CHILE. Chile, 2016

Quimico, UNIVERSIDAD DE CHILE. Chile, 2010

Experiencia Académica

Assistant Professor Full Time

Article (17)

The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency

Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain

Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19

Astrocytes are HIV reservoirs in the brain: A cell type with poor HIV infectivity and replication but efficient cell-to-cell viral transfer

COVID-19 Lung Pathogenesis in SARS-CoV-2 Autopsy Cases

Human immunodeficiency virus-1/simian immunodeficiency virus infection induces opening of pannexin-1 channels resulting in neuronal synaptic compromise: A novel therapeutic opportunity to prevent NeuroHIV

Pannexin-1 channel opening is critical for COVID-19 pathogenesis

Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions

Circulating levels of ATP is a biomarker of HIV cognitive impairment

Role of Tunneling Nanotube-like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread

Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment

Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland

HIV infection and latency induce a unique metabolic signature in human macrophages

Intense White Molecular Fluorescence from Naphthoxazole-Quinoline Derivatives

The role of connexin and pannexin containing channels in the innate and acquired immune response

Experimental and theoretical studies of the photophysics of 7-amino-3-phenyl-2H-benzo[b] [1,4]oxazin-2-one in homogeneous solvents and beta-cyclodextrin aqueous solutions

Solvent and compartmentalization effects on the photophysics of 4-(benzothiazol-2-yl)-N,N-diphenylaniline

Proyecto (1)

PHOTOCHEMICAL AND PHOTOPHYSICAL STUDY OF NEW FLUORECENT DYES. II=> SUBSTITUTED NAPHTHOXAZOLES

Review (5)

HIV infection of astrocytes compromises inter-organelle interactions and inositol phosphate metabolism: A potential mechanism of bystander damage and viral reservoir survival

The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus

Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools

The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis

The Crucial Role of Biofilms in <i>Cryptococcus neoformans</i> Survival within Macrophages and Colonization of the Central Nervous System

Silvana Valdebenito

Gerald Zapata

Agustin Martinez

Juan Saez

GERMAN GUNTHER