Man

Nicolas Andres Crossley Karmelic

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Neuroimaging of psychosis, especially the early stages of the disorder. Particularly interested in network approaches (graph analysis) to understand brain disorders, using functional MRI, DTI, and meta-data.

Educación

  •  Médico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Medical Neurosciences, CHARITE UNIVERSITATSMEDEZIN BERLIN. Alemania, 2006
  •  Neuroimaging, KINGS COLLEGE LONDON. Reino Unido, 2014
  •  General Adult Psychiatrist (CCT), General Medical Council . Reino Unido, 2016
  •  Member of the Royal College of Psychiatrists (MRCPsych), Royal College of Psychiatrists UK. Reino Unido, 2009

Experiencia Académica

  •   Wellcome Clinical Research Fellow Full Time

    KINGS COLLEGE LONDON

    Institute of Psychiatry

    London, Reino Unido

    2011 - 2014

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2014 - A la fecha

  •   NIHR Academic Clinical Fellow Other

    KINGS COLLEGE LONDON

    Institute of Psychiatry

    London, Reino Unido

    2008 - 2011

Experiencia Profesional

  •   Wellcome Clinical Research Fellow Full Time

    King's College London

    London, Reino Unido

    2011 - 2014

  •   National Institute of Health Research UK - Academic Clinical Fellow Full Time

    King's College London

    London, Reino Unido

    2008 - 2011

  •   Senior House Officer in Psychiatry Full Time

    North Essex Partnership NHS Foundation Trust

    London, Chile

    2007 - 2008

  •   Senior House Officer in Psychiatry Full Time

    South London and Maudsley NHS Foundation Trust

    London, Chile

    2006 - 2007

  •   Médico General Part Time

    P. Universidad Católica de Chile - Red de Salud

    Santiago, Chile

    2004 - 2004

  •   Médico de Urgencia Part Time

    Servicio Nacional de Salud Médico Sur Oriente

    Santiago, Chile

    2004 - 2004

  •   Psychiatrist Part Time

    Liga Chile contra la Epilepsia

    Santiago, Chile

    2014 - A la fecha

  •   Assistant Professor Full Time

    P. Universidad Católica de Chile

    Santiago, Chile

    2014 - A la fecha

Formación de Capital Humano


- Supervisor of 1 completed PhD student (Tomás Labbé, Neurociencias UC 2018), and 3 current students (George Gifford, King's College London; Angeles Tepper, Neurociencias UC; Carolina González, Neurociencias UC).
- Lecturer and in charge of undergraduate medical studies of Cognitive Science - chapter within the Neurophysiology course for Medical undergraduate students at Pontificia Universidad Catolica. Lecturer for PhD students at P. Universidad Catolica - specifically leads a course on imaging for cognitive sciences.
- Supervisor of BSc project (Jessica Scott, KCL 2011-2012).
- Lecturer for several Institute of Psychiatry, King's College London, programmes: MSc Mental Health Research (2009, 2013), MRCPsych course (2011 and 2012).
- Facilitator for Interprofessional Education Course KCL (2008).
- Teaching assistant in Gross Anatomy, PUC (1997).


Premios y Distinciones

  •   PhD of the year

    KINGS COLLEGE LONDON

    Reino Unido, 2014

    Prize to the best PhD of the year of the Department of Psychosis Studies.

  •   Wellcome Clinical Research Training Fellowship

    KINGS COLLEGE LONDON

    Chile, 2010

    Award given competitively to doctors in the UK who want to continue an academic career.

  •   NIHR Clinical Academic Fellow

    KINGS COLLEGE LONDON

    Chile, 2007

    Competitive award for doctors in training in the UK given by the National Institute of Health Research UK. It is a open to any specialty, allowing the holder to spend some of their time pursuing academic interests.

  •   Best student of the generation

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2003

    Best student of the cohort graduating that year in Medical School, PUC.

  •   Top national score in Medical Exam

    Asociacion de Facultades de Medicina Chile (ASOFAMECH)

    Chile, 2003

    National top score in exam taken by all medical graduates of that year in Chile

  •   Honor fee

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2001

    Award given to the best student of the generation of that year in Medical School.

  •   Honor fee

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1998

    Award given to the best student of the generation of that year in Medical School.

  •   Beca Santander para académicos jóvenes

    Santander Universidades

    Chile, 2017

    Scholarship providing funds to increase collaborative work with the Universidad Federal de Sao Paulo, Brazil.


 

Article (29)

A pupil size, eye-tracking and neuropsychological dataset from ADHD children during a cognitive task

Rojas-Libano, Daniel; Wainstein, Gabriel; Carrasco, Ximena; Aboitiz, Francisco; Crossley, Nicolas; Ossandon, Tomas

Article ISI SCOPUS
SCIENTIFIC DATA  (2019)

High prevalence of metabolic alterations in Latin American patients at initial stages of psychosis

Iruretagoyena B.; Castañeda C.P.; Undurraga J.; Nachar R.; Mena C.; Gallardo C.; Crossley N.A.; Gonzalez-Valderrama A.

Article ISI SCOPUS
EARLY INTERVENTION IN PSYCHIATRY  (2019)

Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder

Etkin, Amit; Maron-Katz, Adi; Wu, Wei; Fonzo, Gregory A.; Huemer, Julia; Vertes, Petra E.; Patenaude, Brian; Richiardi, Jonas; Goodkind, Madeleine S.; Keller, Corey J.; Ramos-Cejudo, Jaime; Zaiko, Yevgeniya, V; Peng, Kathy K.; Shpigel, Emmanuel; Longwell, Parker; Toll, Russ T.; Thompson, Allison; Zack, Sanno; Gonzalez, Bryan; Edelstein, Raleigh; Chen, Jingyun; Akingbade, Irene; Weiss, Elizabeth; Hart, Roland; Mann, Silas; Durkin, Kathleen; Baete, Steven H.; Boada, Fernando E.; Genfi, Afia; Autea, Jillian; Newman, Jennifer; Oathes, Desmond J.; Lindley, Steven E.; Abu-Amara, Duna; Arnow, Bruce A.; Crossley, Nicolas; Hallmayer, Joachim; Fossati, Silvia; Rothbaum, Barbara O.; Marmar, Charles R.; Bullmore, Edward T.; O'Hara, Ruth

Article ISI SCOPUS
SCIENCE TRANSLATIONAL MEDICINE  (2019)

Early treatment resistance in a Latin-American cohort of patients with schizophrenia.

mena, c; González-Valderrama A; Iruretagoyena, B; Undurraga, J; Crossley, NA

Article
SCHIZOPHRENIA RESEARCH  (2018)

Connectomic correlates of response to treatment in first-episode psychosis.

Crossley, Nicolas A; Marques, Tiago Reis; Taylor, Heather; Chaddock, Chris; Dell'Acqua, Flavio; Reinders, Antje A T S; Mondelli, Valeria; DiForti, Marta; Simmons, Andrew; David, Anthony S; Kapur, Shitij; Pariante, Carmine M; Murray, Robin M; Dazzan, Paola

Article
Brain => a journal of neurology  (2017)

Coordinated brain development=> exploring the synchrony between changes in grey and white matter during childhood maturation.

Moura, L M; Crossley, N A; Zugman, A; Pan, P M; Gadelha, A; Del Aquilla, M A G; Picon, F A; Anés, M; Amaro, E; de Jesus Mari, J; Miguel, E C; Rohde, L A; Bressan, R A; McGuire, P; Sato, J R; Jackowski, A P

Article
Brain imaging and behavior  (2017)

Network-Level Dysconnectivity in Drug-Naïve First-Episode Psychosis=> Dissociating Transdiagnostic and Diagnosis-Specific Alterations.

Gong, Qiyong; Hu, Xinyu; Pettersson-Yeo, William; Xu, Xin; Lui, Su; Crossley, Nicolas; Wu, Min; Zhu, Hongyan; Mechelli, Andrea

Article
Neuropsychopharmacology => official publication of the American College of Neuropsychopharmacology  (2017)

Pupil Size Tracks Attentional Performance In Attention-Deficit/Hyperactivity Disorder

Wainstein, G.; Rojas-Líbano, D.; Crossley, N. A.; Carrasco, X.; Aboitiz, F.; Ossandón, T.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2017)

Structural Network Disorganization in Subjects at Clinical High Risk for Psychosis.

Schmidt, André; Crossley, Nicolas A; Harrisberger, Fabienne; Smieskova, Renata; Lenz, Claudia; Riecher-Rössler, Anita; Lang, Undine E; McGuire, Philip; Fusar-Poli, Paolo; Borgwardt, Stefan

Article
Schizophrenia bulletin  (2017)

Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation

Sato J.R.; Biazoli C.E.; Jr.; Salum G.A.; Gadelha, A; Crossley, N; Vieira, G; Zugman A.; Picon F.A.; Pan P.M.; Hoexter M.Q.; Anés M.; Moura L.M.; Del'Aquilla M.A.G.; Junior E.A.; McGuire P.; Rohde L.A.; Miguel E.C.; Bressan, R.A.; Jackowski A.P.

Article ISI SCOPUS
DEVELOPMENTAL COGNITIVE NEUROSCIENCE  (2016)

Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation

Moura L.M.; Crossley N.A.; Zugman A.; Pan P.M.; Gadelha, A; Del'Aquilla M.A.G.; Picon F.A.; Anés M.; Amaro E.; Jr.; de Jesus Mari J.; Miguel E.C.; Rohde L.A.; Bressan, R.A.; McGuire P.; Sato J.R.; Jackowski A.P.

Article SCOPUS
Brain Imaging and Behavior  (2016)

Default mode network maturation and psychopathology in children and adolescents

Sato, JR; Salum, GA; Gadelha, A; Crossley, N; Vieira, G; Manfro, GG; Zugman A.; Picon, FA; Pan, PM; Hoexter, MQ; Anés M.; Moura, LM; Del'Aquilla, MAG; Amaro E.; McGuire P.; Lacerda, ALT; Rohde, LA; Miguel, EC; Jackowski, AP; Bressan, RA

Article ISI
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY  (2016)

HPA-axis function and grey matter volume reductions: imaging the diathesis-stress model in individuals at ultra-high risk of psychosis

Valli I.; Crossley N.A.; Day F.; Stone, J; Tognin S.; Mondelli V.; Howes O.; Valmaggia, L; Pariante C.; McGuire P.

Article ISI SCOPUS
TRANSLATIONAL PSYCHIATRY  (2016)

Whole-Brain Atrophy Rate in Idiopathic Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy

Guevara, C; Bulatova, K; Barker, G. J.; Gonzalez G. ; Crossley, N; Kempton M.J.

Article ISI SCOPUS
PARKINSONS DISEASE  (2016)

Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study

Sato, JR; Salum, GA; Gadelha, A; Vieira, G; Zugman A.; Picon, FA; Pan, PM; Hoexter, MQ; Anés M.; Moura, LM; Del'Aquilla, MAG; Crossley, N; Amaro E.; McGuire P.; Lacerda, ALT; Rohde, LA; Miguel, EC; Jackowski, AP; Bressan, RA

Article ISI
NEUROIMAGE  (2015)

Neuroimaging distinction between neurological and psychiatric disorders.

Crossley NA, Scott J, Ellison-Wright I, Mechelli A.

Article
Br J Psychiatry  (2015)

Quantitative Prediction of Individual Psychopathology in Trauma Survivors Using Resting-State fMRI

Gong, QY; Li, LJ; Du, MY; Pettersson-Yeo, W; Crossley, N; Yang, X; Li, J; Huang, XQ; Mechelli, A

Article ISI
NEUROPSYCHOPHARMACOLOGY  (2014)

The hubs of the human connectome are generally implicated in the anatomy of brain disorders.

Crossley NA; Mechelli A; Scott J; Carletti F; Fox PT; McGuire P; Bullmore ET

Article
Brain  (2014)

Cognitive relevance of the community structure of the human brain functional coactivation network.

Crossley NA; Mechelli A; Vértes PE; Winton-Brown TT; Patel AX; Ginestet CE; McGuire P; Bullmore ET

Article
Proc Natl Acad Sci U S A  (2013)

Neurophysiological alterations in the prepsychotic phases.

Crossley NA; Constante M; Fusar-Poli P; Bramon E

Article
Curr Pharm Des  (2012)

Gray matter alterations related to P300 abnormalities in subjects at high risk for psychosis: Longitudinal MRI-EEG study

Fusar-Poli P; Crossley, N; Woolley, J; Carletti, F; Perez-Iglesias, R; Broome, M; Johns, L; Tabraham, P; Bramon, E; McGuire P.

Article ISI
NEUROIMAGE  (2011)

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG study

Fusar-Poli P; Crossley, N; Woolley, J; Carletti, F; Perez-Iglesias, R; Broome, M; Johns, L; Tabraham, P; Bramon, E; McGuire P.

Article ISI
JOURNAL OF PSYCHIATRY & NEUROSCIENCE  (2011)

Efficacy of atypical v. typical antipsychotics in the treatment of early psychosis: meta-analysis.

Crossley NA; Constante M; McGuire P; Power P

Article
Br J Psychiatry  (2010)

Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis.

Crossley, NA; Mechelli, A; Fusar-Poli P; Broome, MR; Matthiasson P; Johns LC; Bramon, E; Valmaggia, L; Williams, SC; McGuire PK

Article ISI
Hum Brain Mapp  (2009)

Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials.

Crossley, NA; Bauer M.

Article ISI
J Clin Psychiatry  (2007)

Renal transplants with delayed graft function show decreased renal function despite monitoring with postabsorptive levels

Dominguez J.; González A; Crossley, N; Norambuena R.

Article ISI
TRANSPLANTATION PROCEEDINGS  (2004)

[Critical appraisal: Subcutaneous adjusted-dose unfractionated heparin vs fixed-dose low-molecular-weight heparin in the initial treatment of venous thromboembolism. Prandoni P, Carnovali M, Marchiori A, Galilei investigators. Arch Intern Med 2004; 164: 1077-83].

Burotto, M; Gabrieli L; Crossley, N

Article
Rev Med Chile  

Age effects on the default mode and control networks in typically developing children.

Sato, J; Salum, GA; Gadelha, A; Picon, FA; Pan, PM; Vieira, G; Zugman A.; Hoexter, MQ; Anés M.; Moura, LM; Gomes Dell'Aquila MA; Amaro E Junior; McGuire P.; Crossley, N; Lacerda A; Rhode LA; Miguel, EC; Bressan, RA; Jackowski, AP

Article ISI
J Psychiatr Res  

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.

Crossley, NA; Sena E; Goehler J; Horn, J; van der Worp B; Bath, PM; Macleod, M; Dirnagl U

Article ISI
STROKE  

BookSection (3)

Neurophysiological alterations in the pre-psychotic phases

Crossley, N; Bramon, E

BookSection
 (2012)

The Acute Antidepressant Effects of Lithium: from Monotherapy to Augmentation Therapy in Major Depressive Episodes

Bauer M.; Crossley, NA; Gerber S; Bschor T; Bauer M.; Grof P.; Muller-Oerlinghausen B

BookSection
 (2006)

The Position of Lithium in International and National Guidelines for the Treatment of Mood Disorders

Crossley, NA; Muller-Oerlinghausen B; Glenn T.; Bauer M.; Bauer M.; Grof P.; Muller-Oerlinghausen B

BookSection
 (2006)

Proyecto (3)

Ibero-American Network for the study of early psychosis

Crossley, Nicolas

Proyecto Network of 15 groups from 6 Latin American countries (Argentina, Brazil, Bolivia, Chile, Colombia and Mexico) who are studying early psychosis. Dr. Crossley is the director of the network.
 (2018)

A CONNECTOMIC NEUROIMAGING STUDY OF THE 22Q11 DELETION SYNDROME: A WINDOW INTO SCHIZOPHRENIA AND ITS GENETIC CAUSES

Crossley, Nicolas; Repetto, Gabriela; Juan Pablo Undurraga

Proyecto Connectomic neuroimaging study looking at structural and functional networks from DTI and resting-state fMRI, comparing a cohort of patients with high genetic risk (22q11 deletion sd), with healthy subjects and patients with schizophrenia.
 (2016)

Network dynamics and neural circuits of the brain during resting-state in health and disease

Ossandon, Tomas; Crossley, Nicolas; Fuentealba, Pablo; Fuenzalida, Marco

Proyecto Study looking at spontaneous brain activity at rest, at different levels (from cells, animals to human beings) and in health and disease (particularly psychosis and epilepsy).
 (0)

Review (1)

Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies

Crossley N.A.; Alliende L.M.; Ossandon T.; Castañeda C.P.; González-Valderrama A.; Undurraga J.; Castro M.; Guinjoan, S; Díaz-Zuluaga A.M.; Pineda-Zapata J.A.; López-Jaramillo C.; Reyes-Madrigal F.; León-Ortíz P.; de la Fuente-Sandoval C.; Czepielewski L.S.; Gama C.S.; Zugman A.; Gadelha, A; Jackowski A.; Bressan R.

Review ISI SCOPUS
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING  (2019)

27
Nicolas Crossley

Assistant Professor

Psiquiatría

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Tomás Ossandón

Associate Professor

Medical School, Department of Psychiatry

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Juan Undurraga

Psychiatrist

Neurología y Psiquiatría

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

Santiago, Chile

2
Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

2
ALFONSO GONZALEZ

PROFESOR ASISTENTE

SALUD MENTAL

Universidad Finis Terrae

santiago, Chile

2
Daniel Rojas

Profesor

Universidad Diego Portales

Santiago, Chile

1
Carlos Guevara

Profesor Asistente

Neurologia y Neurocirugía

Hospital Clínico de la Universidad de Chile

Santiago, Chile